Statins, ACE/ARBs drug use, and risk of pneumonia in hospitalized older patients : a retrospective cohort study
© 2024. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI)..
The aims of this study is to evaluate the association between angiotensin-converting enzyme inhibitor (ACE-I), angiotensin II receptor blocker (ARBs) and/or statin use with the risk of pneumonia, as well as and with in-hospital and short-term outpatient mortality in hospitalized older patients with pneumonia. Patients aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro Politerapuie SIMI-Società Italiana di Medicina Interna) register from 2010 to 2019 were screened to assess the diagnosis of pneumonia and classified on whether or not they were prescribed with at least one drug among ACE-I, ARBs, and/or statins. Further study outcomes were mortality during hospital stay and at 3 months after hospital discharge. Among 5717 cases included (of whom 18.0% with pneumonia), 2915 (51.0%) were prescribed at least one drug among ACE-I, ARBs, and statins. An inverse association was found between treatment with ACE-I or ARBs and pneumonia (OR = 0.79, 95% CI 0.65-0.95). A higher effect was found among patients treated with ACE-I or ARBs in combination with statins (OR = 0.67, 95% CI 0.52-0.85). This study confirmed in the real-world setting that these largely used medications may reduce the risk of pneumonia in older people, who chronically take them for cardiovascular conditions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Internal and emergency medicine - 19(2024), 3 vom: 01. Apr., Seite 689-696 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Franchi, Carlotta [VerfasserIn] |
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| Links: |
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| Themen: |
ACE inhibitors |
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| Anmerkungen: |
Date Completed 23.04.2024 Date Revised 23.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11739-023-03528-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368439933 |
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| 100 | 1 | |a Franchi, Carlotta |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Statins, ACE/ARBs drug use, and risk of pneumonia in hospitalized older patients |b a retrospective cohort study |
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| 520 | |a © 2024. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI). | ||
| 520 | |a The aims of this study is to evaluate the association between angiotensin-converting enzyme inhibitor (ACE-I), angiotensin II receptor blocker (ARBs) and/or statin use with the risk of pneumonia, as well as and with in-hospital and short-term outpatient mortality in hospitalized older patients with pneumonia. Patients aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro Politerapuie SIMI-Società Italiana di Medicina Interna) register from 2010 to 2019 were screened to assess the diagnosis of pneumonia and classified on whether or not they were prescribed with at least one drug among ACE-I, ARBs, and/or statins. Further study outcomes were mortality during hospital stay and at 3 months after hospital discharge. Among 5717 cases included (of whom 18.0% with pneumonia), 2915 (51.0%) were prescribed at least one drug among ACE-I, ARBs, and statins. An inverse association was found between treatment with ACE-I or ARBs and pneumonia (OR = 0.79, 95% CI 0.65-0.95). A higher effect was found among patients treated with ACE-I or ARBs in combination with statins (OR = 0.67, 95% CI 0.52-0.85). This study confirmed in the real-world setting that these largely used medications may reduce the risk of pneumonia in older people, who chronically take them for cardiovascular conditions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ACE inhibitors | |
| 650 | 4 | |a ARBs | |
| 650 | 4 | |a Older people | |
| 650 | 4 | |a Pneumonia | |
| 650 | 4 | |a Statins | |
| 650 | 7 | |a Angiotensin-Converting Enzyme Inhibitors |2 NLM | |
| 650 | 7 | |a Hydroxymethylglutaryl-CoA Reductase Inhibitors |2 NLM | |
| 650 | 7 | |a Angiotensin Receptor Antagonists |2 NLM | |
| 700 | 1 | |a Rossio, Raffaella |e verfasserin |4 aut | |
| 700 | 1 | |a Mandelli, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Ardoino, Ilaria |e verfasserin |4 aut | |
| 700 | 1 | |a Nobili, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Peyvandi, Flora |e verfasserin |4 aut | |
| 700 | 1 | |a Mannucci, Pier Mannuccio |e verfasserin |4 aut | |
| 700 | 0 | |a REPOSI Investigators |e verfasserin |4 aut | |
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