Ion channel TRPV2 is critical in enhancing B cell activation and function
© 2024 Li et al..
The function of transient receptor potential vanilloid (TRPV) cation channels governing B cell activation remains to be explored. We present evidence that TRPV2 is highly expressed in B cells and plays a crucial role in the formation of the B cell immunological synapse and B cell activation. Physiologically, TRPV2 expression level is positively correlated to influenza-specific antibody production and is low in newborns and seniors. Pathologically, a positive correlation is established between TRPV2 expression and the clinical manifestations of systemic lupus erythematosus (SLE) in adult and child SLE patients. Correspondingly, mice with deficient TRPV2 in B cells display impaired antibody responses following immunization. Mechanistically, the pore and N-terminal domains of TRPV2 are crucial for gating cation permeation and executing mechanosensation in B cells upon antigen stimulation. These processes synergistically contribute to membrane potential depolarization and cytoskeleton remodeling within the B cell immunological synapse, fostering efficient B cell activation. Thus, TRPV2 is critical in augmenting B cell activation and function.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:221 |
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| Enthalten in: |
The Journal of experimental medicine - 221(2024), 3 vom: 04. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Cuifeng [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Viral |
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| Anmerkungen: |
Date Completed 15.02.2024 Date Revised 16.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1084/jem.20221042 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The function of transient receptor potential vanilloid (TRPV) cation channels governing B cell activation remains to be explored. We present evidence that TRPV2 is highly expressed in B cells and plays a crucial role in the formation of the B cell immunological synapse and B cell activation. Physiologically, TRPV2 expression level is positively correlated to influenza-specific antibody production and is low in newborns and seniors. Pathologically, a positive correlation is established between TRPV2 expression and the clinical manifestations of systemic lupus erythematosus (SLE) in adult and child SLE patients. Correspondingly, mice with deficient TRPV2 in B cells display impaired antibody responses following immunization. Mechanistically, the pore and N-terminal domains of TRPV2 are crucial for gating cation permeation and executing mechanosensation in B cells upon antigen stimulation. These processes synergistically contribute to membrane potential depolarization and cytoskeleton remodeling within the B cell immunological synapse, fostering efficient B cell activation. Thus, TRPV2 is critical in augmenting B cell activation and function | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Ion Channels |2 NLM | |
| 650 | 7 | |a Antibodies, Viral |2 NLM | |
| 650 | 7 | |a Cations |2 NLM | |
| 650 | 7 | |a TRPV2 protein, human |2 NLM | |
| 650 | 7 | |a TRPV Cation Channels |2 NLM | |
| 700 | 1 | |a Zhao, Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiaohang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yuxin |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Bihua |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Lina |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Xiaolin |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Wenbo |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Na |e verfasserin |4 aut | |
| 700 | 1 | |a Ji, Zhenglin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Tong |e verfasserin |4 aut | |
| 700 | 1 | |a An, Haoran |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Fei |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Chuan |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Jing-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jing-Ren |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Qingwen |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Xiaodong |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zhanguo |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Wanli |e verfasserin |4 aut | |
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