Abnormal Changes in IL-13 and IL-17A Serum Levels in Children with Adenovirus Pneumonia and their Diagnostic Value
Background: Human adenovirus (HAdV) is an enveloped icosahedral DNA virus. HAdV infection can lead to immune system damage, resulting in decreased numbers and compromised function of T cells and B cells. It can also cause an imbalanced Th1/Th2 ratio and dysregulation of pro-inflammatory and anti-inflammatory cytokines.
Objective: To investigate the serum levels of interleukin (IL)-13 and IL-17A in children with HAdV pneumonia.
Methods: Pediatric patients diagnosed with HAdV pneumonia were divided into a non-severe group or a severe group based on the severity of their condition. Patients in the severe group were further classified into good and poor prognosis subgroups. We collected 2-2.5 mL of venous blood from each patient, which was then centrifuged. Using an ELISA detection kit, we determined the concentrations of IL-13 and IL-17A.
Results: Patients with a severe condition exhibited significantly higher serum concentrations of IL-13 and IL-17A than the non-severe cases. Out of 50 severe cases, 32 had good prognoses, while 18 cases showed poor prognoses. Patients with poor prognoses showed significantly higher serum concentrations of IL-13 compared to those with good prognoses.
Conclusion: Serum concentrations of IL-13 and IL-17A are potential diagnostic markers for pediatric patients with severe HAdV pneumonia. Additionally, they demonstrate good predictive value for a poor prognosis in severe pneumonia cases.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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Enthalten in: |
Iranian journal of immunology : IJI - 21(2024), 1 vom: 12. März, Seite 81-88 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Jiang, Jianbo [VerfasserIn] |
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Links: |
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Themen: |
Adenovirus |
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Anmerkungen: |
Date Completed 13.03.2024 Date Revised 13.03.2024 published: Electronic Citation Status MEDLINE |
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doi: |
10.22034/iji.2024.99509.2648 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM368378101 |
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520 | |a Background: Human adenovirus (HAdV) is an enveloped icosahedral DNA virus. HAdV infection can lead to immune system damage, resulting in decreased numbers and compromised function of T cells and B cells. It can also cause an imbalanced Th1/Th2 ratio and dysregulation of pro-inflammatory and anti-inflammatory cytokines | ||
520 | |a Objective: To investigate the serum levels of interleukin (IL)-13 and IL-17A in children with HAdV pneumonia | ||
520 | |a Methods: Pediatric patients diagnosed with HAdV pneumonia were divided into a non-severe group or a severe group based on the severity of their condition. Patients in the severe group were further classified into good and poor prognosis subgroups. We collected 2-2.5 mL of venous blood from each patient, which was then centrifuged. Using an ELISA detection kit, we determined the concentrations of IL-13 and IL-17A | ||
520 | |a Results: Patients with a severe condition exhibited significantly higher serum concentrations of IL-13 and IL-17A than the non-severe cases. Out of 50 severe cases, 32 had good prognoses, while 18 cases showed poor prognoses. Patients with poor prognoses showed significantly higher serum concentrations of IL-13 compared to those with good prognoses | ||
520 | |a Conclusion: Serum concentrations of IL-13 and IL-17A are potential diagnostic markers for pediatric patients with severe HAdV pneumonia. Additionally, they demonstrate good predictive value for a poor prognosis in severe pneumonia cases | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Adenovirus | |
650 | 4 | |a Interleukin-13 | |
650 | 4 | |a Interleukin-17A | |
650 | 4 | |a Pediatrics | |
650 | 4 | |a Severe Pneumonia | |
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650 | 7 | |a Interleukin-17 |2 NLM | |
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700 | 1 | |a Huang, Meixia |e verfasserin |4 aut | |
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