Coordination between circadian neural circuit and intracellular molecular clock ensures rhythmic activation of adult neural stem cells
The circadian clock throughout the day organizes the activity of neural stem cells (NSCs) in the dentate gyrus (DG) of adult hippocampus temporally. However, it is still unclear whether and how circadian signals from the niches contribute to daily rhythmic variation of NSC activation. Here, we show that norepinephrinergic (NEergic) projections from the locus coeruleus (LC), a brain arousal system, innervate into adult DG, where daily rhythmic release of norepinephrine (NE) from the LC NEergic neurons controlled circadian variation of NSC activation through β3-adrenoceptors. Disrupted circadian rhythmicity by acute sleep deprivation leads to transient NSC overactivation and NSC pool exhaustion over time, which is effectively ameliorated by the inhibition of the LC NEergic neuronal activity or β3-adrenoceptors-mediated signaling. Finally, we demonstrate that NE/β3-adrenoceptors-mediated signaling regulates NSC activation through molecular clock BMAL1. Therefore, our study unravels that adult NSCs precisely coordinate circadian neural circuit and intrinsic molecular circadian clock to adapt their cellular behavior across the day.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:121 |
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| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 121(2024), 8 vom: 20. Feb., Seite e2318030121 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Qiang [VerfasserIn] |
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| Links: |
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| Themen: |
Adult neurogenesis |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 28.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1073/pnas.2318030121 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368363139 |
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| 245 | 1 | 0 | |a Coordination between circadian neural circuit and intracellular molecular clock ensures rhythmic activation of adult neural stem cells |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The circadian clock throughout the day organizes the activity of neural stem cells (NSCs) in the dentate gyrus (DG) of adult hippocampus temporally. However, it is still unclear whether and how circadian signals from the niches contribute to daily rhythmic variation of NSC activation. Here, we show that norepinephrinergic (NEergic) projections from the locus coeruleus (LC), a brain arousal system, innervate into adult DG, where daily rhythmic release of norepinephrine (NE) from the LC NEergic neurons controlled circadian variation of NSC activation through β3-adrenoceptors. Disrupted circadian rhythmicity by acute sleep deprivation leads to transient NSC overactivation and NSC pool exhaustion over time, which is effectively ameliorated by the inhibition of the LC NEergic neuronal activity or β3-adrenoceptors-mediated signaling. Finally, we demonstrate that NE/β3-adrenoceptors-mediated signaling regulates NSC activation through molecular clock BMAL1. Therefore, our study unravels that adult NSCs precisely coordinate circadian neural circuit and intrinsic molecular circadian clock to adapt their cellular behavior across the day | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a adult neurogenesis | |
| 650 | 4 | |a circadian rhythm | |
| 650 | 4 | |a neural stem cells | |
| 650 | 4 | |a norepinephrine | |
| 650 | 7 | |a Receptors, Adrenergic |2 NLM | |
| 700 | 1 | |a Luo, Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Ziqi |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Dezhe |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Mingyue |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Weixiang |e verfasserin |4 aut | |
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