Synthetic Catalysts for Selective Glycan Cleavage from Glycoproteins and Cells
In situ modification of glycans requires extraordinary molecular recognition of highly complex and subtly different carbohydrates, followed by reactions at precise locations on the substrate. We here report synthetic catalysts that under physiological conditions cleave a predetermined oligosaccharide block such as a branched trimannose or the entire N-glycan of a glycoprotein, while nontargeted glycoproteins stay intact. The method also allows α2-6-sialylated galactosides to be removed preferentially over the α2-3-linked ones from cell surfaces, highlighting the potential of these synthetic glycosidases for glycan editing.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:146 |
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| Enthalten in: |
Journal of the American Chemical Society - 146(2024), 7 vom: 21. Feb., Seite 4346-4350 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zangiabadi, Milad [VerfasserIn] |
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| Links: |
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| Themen: |
EC 3.2.1.- |
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| Anmerkungen: |
Date Completed 22.02.2024 Date Revised 22.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/jacs.3c13700 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM368361489 |
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| 520 | |a In situ modification of glycans requires extraordinary molecular recognition of highly complex and subtly different carbohydrates, followed by reactions at precise locations on the substrate. We here report synthetic catalysts that under physiological conditions cleave a predetermined oligosaccharide block such as a branched trimannose or the entire N-glycan of a glycoprotein, while nontargeted glycoproteins stay intact. The method also allows α2-6-sialylated galactosides to be removed preferentially over the α2-3-linked ones from cell surfaces, highlighting the potential of these synthetic glycosidases for glycan editing | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Ghosh, Avijit |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Hai |e verfasserin |4 aut | |
| 700 | 1 | |a Agrahari, Anand Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yan |e verfasserin |4 aut | |
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