The human papillomavirus late life cycle and links to keratinocyte differentiation
© 2024 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC..
Regulation of human papillomavirus (HPV) gene expression is tightly linked to differentiation of the keratinocytes the virus infects. HPV late gene expression is confined to the cells in the upper layers of the epithelium where the virus capsid proteins are synthesized. As these proteins are highly immunogenic, and the upper epithelium is an immune-privileged site, this spatial restriction aids immune evasion. Many decades of work have contributed to the current understanding of how this restriction occurs at a molecular level. This review will examine what is known about late gene expression in HPV-infected lesions and will dissect the intricacies of late gene regulation. Future directions for novel antiviral approaches will be highlighted.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:96 |
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| Enthalten in: |
Journal of medical virology - 96(2024), 2 vom: 28. Feb., Seite e29461 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kirk, Anna [VerfasserIn] |
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| Links: |
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| Themen: |
Gene regulation |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 06.03.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1002/jmv.29461 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Regulation of human papillomavirus (HPV) gene expression is tightly linked to differentiation of the keratinocytes the virus infects. HPV late gene expression is confined to the cells in the upper layers of the epithelium where the virus capsid proteins are synthesized. As these proteins are highly immunogenic, and the upper epithelium is an immune-privileged site, this spatial restriction aids immune evasion. Many decades of work have contributed to the current understanding of how this restriction occurs at a molecular level. This review will examine what is known about late gene expression in HPV-infected lesions and will dissect the intricacies of late gene regulation. Future directions for novel antiviral approaches will be highlighted | ||
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