Dynamic m6 A profiles reveal the role of YTHDC2-TLR2 signaling axis in Talaromyces marneffei infection
© 2024 Wiley Periodicals LLC..
Talaromyces marneffei (TM) immune evasion is an important factor leading to the high mortality rate of Penicilliosis marneffei. N6 -methyladenosine (m6 A) plays important roles in host immune response to various pathogen infections, yet its role in TM and HIV/TM coinfection remains largely unexplored. Here we reported genome-wide transcriptional m6 A profiles of TM mono-infection and HIV/TM coinfection. Our finding revealed dynamic alterations in global m6 A levels and upregulation of the m6 A reader YTH N6 -methyladenosine RNA binding protein C2 (YTHDC2) in TM-infected macrophages. Knockdown of YTHDC2 in TM-infected cells showed an elevated expression of TLR2 through m6 A-dependence, along with upregulation of TNF-α and IL1-β. Overall, we characterized the m6 A profiles of the host and fungus before and after TM infection, and demonstrated that YTHDC2 mediates the key m6 A site of TLR2 to exert its function. These findings provide new insights into the underlying mechanisms and novel therapeutic approaches for TM diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:96 |
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| Enthalten in: |
Journal of medical virology - 96(2024), 2 vom: 12. Feb., Seite e29466 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chu, Jiemei [VerfasserIn] |
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| Links: |
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| Themen: |
EC 3.6.4.13 |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 14.02.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1002/jmv.29466 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM368350770 |
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| 245 | 1 | 0 | |a Dynamic m6 A profiles reveal the role of YTHDC2-TLR2 signaling axis in Talaromyces marneffei infection |
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| 520 | |a Talaromyces marneffei (TM) immune evasion is an important factor leading to the high mortality rate of Penicilliosis marneffei. N6 -methyladenosine (m6 A) plays important roles in host immune response to various pathogen infections, yet its role in TM and HIV/TM coinfection remains largely unexplored. Here we reported genome-wide transcriptional m6 A profiles of TM mono-infection and HIV/TM coinfection. Our finding revealed dynamic alterations in global m6 A levels and upregulation of the m6 A reader YTH N6 -methyladenosine RNA binding protein C2 (YTHDC2) in TM-infected macrophages. Knockdown of YTHDC2 in TM-infected cells showed an elevated expression of TLR2 through m6 A-dependence, along with upregulation of TNF-α and IL1-β. Overall, we characterized the m6 A profiles of the host and fungus before and after TM infection, and demonstrated that YTHDC2 mediates the key m6 A site of TLR2 to exert its function. These findings provide new insights into the underlying mechanisms and novel therapeutic approaches for TM diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a TLR2 | |
| 650 | 4 | |a Talaromyces marneffei | |
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| 700 | 1 | |a Zheng, Ruili |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Hubin |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yaxin |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jingyi |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Wudi |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Rongfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Peixue |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Jinming |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Junjun |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a An, Sanqi |e verfasserin |4 aut | |
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