Oral COVID-19 Antiviral Uptake Among a Highly Vaccinated US Cohort of Adults With SARS-CoV-2 Infection Between December 2021 and October 2022
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America..
Background: We described the oral nirmatrelvir/ritonavir (NMV/r) and molnupiravir (MOV) uptake among a subgroup of highly vaccinated adults in a US national prospective cohort who were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between 12/2021 and 10/2022.
Methods: We estimate antiviral uptake within 5 days of SARS-CoV-2 infection, as well as age- and gender-adjusted antiviral uptake prevalence ratios by antiviral eligibility (based on age and comorbidities), sociodemographic characteristics, and clinical characteristics including vaccination status and history of long coronavirus disease 2019 (COVID).
Results: NMV/r uptake was 13.6% (95% CI, 11.9%-15.2%) among 1594 participants, and MOV uptake was 1.4% (95% CI, 0.8%-2.1%) among 1398 participants. NMV/r uptake increased over time (1.9%; 95% CI, 1.0%-2.9%; between 12/2021 and 3/2022; 16.5%; 95% CI, 13.0%-20.0%; between 4/2022 and 7/2022; and 25.3%; 95% CI, 21.6%-29.0%; between 8/2022 and 10/2022). Participants age ≥65 and those who had comorbidities for severe COVID-19 had higher NMV/r uptake. There was lower NMV/r uptake among non-Hispanic Black participants (7.2%; 95% CI, 2.4%-12.0%; relative to other racial/ethnic groups) and among individuals in the lowest income groups (10.6%; 95% CI, 7.3%-13.8%; relative to higher income groups). Among a subset of 278 participants with SARS-CoV-2 infection after 12/2021 who also had a history of prior SARS-CoV-2 infection, those with (vs without) a history of long COVID reported greater NMV/r uptake (22.0% vs 7.9%; P = .001). Among those prescribed NMV/r (n = 216), 137 (63%; 95% CI, 57%-70%) reported that NMV/r was helpful for reducing COVID-19 symptoms.
Conclusions: Despite proven effectiveness against severe outcomes, COVID-19 antiviral uptake remains low among those with SARS-CoV-2 infection in the United States. Further outreach to providers and patients to improve awareness of COVID-19 oral antivirals and indications is needed.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
---|---|
Enthalten in: |
Open forum infectious diseases - 11(2024), 2 vom: 11. Feb., Seite ofad674 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Shen, Yanhan [VerfasserIn] |
---|
Links: |
---|
Themen: |
Awareness of antivirals |
---|
Anmerkungen: |
Date Revised 18.02.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.1093/ofid/ofad674 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM368342808 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM368342808 | ||
003 | DE-627 | ||
005 | 20240218231940.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240213s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1093/ofid/ofad674 |2 doi | |
028 | 5 | 2 | |a pubmed24n1298.xml |
035 | |a (DE-627)NLM368342808 | ||
035 | |a (NLM)38344131 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Shen, Yanhan |e verfasserin |4 aut | |
245 | 1 | 0 | |a Oral COVID-19 Antiviral Uptake Among a Highly Vaccinated US Cohort of Adults With SARS-CoV-2 Infection Between December 2021 and October 2022 |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 18.02.2024 | ||
500 | |a published: Electronic-eCollection | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. | ||
520 | |a Background: We described the oral nirmatrelvir/ritonavir (NMV/r) and molnupiravir (MOV) uptake among a subgroup of highly vaccinated adults in a US national prospective cohort who were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between 12/2021 and 10/2022 | ||
520 | |a Methods: We estimate antiviral uptake within 5 days of SARS-CoV-2 infection, as well as age- and gender-adjusted antiviral uptake prevalence ratios by antiviral eligibility (based on age and comorbidities), sociodemographic characteristics, and clinical characteristics including vaccination status and history of long coronavirus disease 2019 (COVID) | ||
520 | |a Results: NMV/r uptake was 13.6% (95% CI, 11.9%-15.2%) among 1594 participants, and MOV uptake was 1.4% (95% CI, 0.8%-2.1%) among 1398 participants. NMV/r uptake increased over time (1.9%; 95% CI, 1.0%-2.9%; between 12/2021 and 3/2022; 16.5%; 95% CI, 13.0%-20.0%; between 4/2022 and 7/2022; and 25.3%; 95% CI, 21.6%-29.0%; between 8/2022 and 10/2022). Participants age ≥65 and those who had comorbidities for severe COVID-19 had higher NMV/r uptake. There was lower NMV/r uptake among non-Hispanic Black participants (7.2%; 95% CI, 2.4%-12.0%; relative to other racial/ethnic groups) and among individuals in the lowest income groups (10.6%; 95% CI, 7.3%-13.8%; relative to higher income groups). Among a subset of 278 participants with SARS-CoV-2 infection after 12/2021 who also had a history of prior SARS-CoV-2 infection, those with (vs without) a history of long COVID reported greater NMV/r uptake (22.0% vs 7.9%; P = .001). Among those prescribed NMV/r (n = 216), 137 (63%; 95% CI, 57%-70%) reported that NMV/r was helpful for reducing COVID-19 symptoms | ||
520 | |a Conclusions: Despite proven effectiveness against severe outcomes, COVID-19 antiviral uptake remains low among those with SARS-CoV-2 infection in the United States. Further outreach to providers and patients to improve awareness of COVID-19 oral antivirals and indications is needed | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a CHASING COVID Cohort study | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a awareness of antivirals | |
650 | 4 | |a molnupiravir (MOV) | |
650 | 4 | |a nirmatrelvir-ritonavir (NMV/r) | |
700 | 1 | |a Robertson, McKaylee M |e verfasserin |4 aut | |
700 | 1 | |a Kulkarni, Sarah G |e verfasserin |4 aut | |
700 | 1 | |a Puzniak, Laura |e verfasserin |4 aut | |
700 | 1 | |a Zamparo, Joann M |e verfasserin |4 aut | |
700 | 1 | |a Allen, Kristen E |e verfasserin |4 aut | |
700 | 1 | |a Porter, Thomas M |e verfasserin |4 aut | |
700 | 1 | |a Qasmieh, Saba A |e verfasserin |4 aut | |
700 | 1 | |a Grov, Christian |e verfasserin |4 aut | |
700 | 1 | |a Srivastava, Avantika |e verfasserin |4 aut | |
700 | 1 | |a Zimba, Rebecca |e verfasserin |4 aut | |
700 | 1 | |a McLaughlin, John M |e verfasserin |4 aut | |
700 | 1 | |a Nash, Denis |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Open forum infectious diseases |d 2014 |g 11(2024), 2 vom: 11. Feb., Seite ofad674 |w (DE-627)NLM243576811 |x 2328-8957 |7 nnns |
773 | 1 | 8 | |g volume:11 |g year:2024 |g number:2 |g day:11 |g month:02 |g pages:ofad674 |
856 | 4 | 0 | |u http://dx.doi.org/10.1093/ofid/ofad674 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 11 |j 2024 |e 2 |b 11 |c 02 |h ofad674 |