Detailed tracking of antigen and antibody levels during coronavirus disease 2019 treatment in an immunosuppressed patient with anti-neutrophil cytoplasmic autoantibody-associated vasculitis
Copyright © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved..
A 67-year-old woman with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis was not vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and was on multiple immunosuppressive drugs. She was hospitalized because of interstitial shadowing in the lungs and diagnosed with persistent coronavirus disease 2019 (COVID-19). Despite treatment with a recombinant monoclonal antibody and antivirals, her symptoms persisted and she lacked a specific antibody response. She tested negative for SARS-CoV-2 antigen after the second antiviral treatment, and a subsequent chest radiograph showed improvement. However, the antibody levels did not change. This case highlights the importance of careful monitoring of the SARS-CoV-2 antigen and antibody levels during COVID-19 treatment in patients with immunosuppression.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - (2024) vom: 10. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yukishima, Toshitaka [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-neutrophil cytoplasmic antibody-associated vasculitis |
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| Anmerkungen: |
Date Revised 15.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.jiac.2024.02.004 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368317072 |
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| 245 | 1 | 0 | |a Detailed tracking of antigen and antibody levels during coronavirus disease 2019 treatment in an immunosuppressed patient with anti-neutrophil cytoplasmic autoantibody-associated vasculitis |
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| 520 | |a Copyright © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a A 67-year-old woman with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis was not vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and was on multiple immunosuppressive drugs. She was hospitalized because of interstitial shadowing in the lungs and diagnosed with persistent coronavirus disease 2019 (COVID-19). Despite treatment with a recombinant monoclonal antibody and antivirals, her symptoms persisted and she lacked a specific antibody response. She tested negative for SARS-CoV-2 antigen after the second antiviral treatment, and a subsequent chest radiograph showed improvement. However, the antibody levels did not change. This case highlights the importance of careful monitoring of the SARS-CoV-2 antigen and antibody levels during COVID-19 treatment in patients with immunosuppression | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Coronavirus disease 2019 | |
| 650 | 4 | |a Nirmatrelvir/ritonavir | |
| 650 | 4 | |a SARS-CoV-2 antibody | |
| 650 | 4 | |a SARS-CoV-2 antigen | |
| 650 | 4 | |a anti-neutrophil cytoplasmic antibody-associated vasculitis | |
| 650 | 4 | |a sotrovimab | |
| 700 | 1 | |a Furuhashi, Kazuki |e verfasserin |4 aut | |
| 700 | 1 | |a Shimoyama, Kumiko |e verfasserin |4 aut | |
| 700 | 1 | |a Taki, Takeru |e verfasserin |4 aut | |
| 700 | 1 | |a Azuma, Chika |e verfasserin |4 aut | |
| 700 | 1 | |a Yamazaki, Kenji |e verfasserin |4 aut | |
| 700 | 1 | |a Furukawa, Shogo |e verfasserin |4 aut | |
| 700 | 1 | |a Fukami, Soma |e verfasserin |4 aut | |
| 700 | 1 | |a Nagura, Osanori |e verfasserin |4 aut | |
| 700 | 1 | |a Katahashi, Kazuto |e verfasserin |4 aut | |
| 700 | 1 | |a Yamashita, Keita |e verfasserin |4 aut | |
| 700 | 1 | |a Maekawa, Masato |e verfasserin |4 aut | |
| 700 | 1 | |a Ogawa, Noriyoshi |e verfasserin |4 aut | |
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