Preventable or potentially inappropriate psychotropics and adverse health outcomes in older adults : systematic review and meta-analysis
Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved..
OBJECTIVE: To systematically review and quantitatively synthetize evidence on the use of PIPs linked to adverse health outcomes in older adults.
METHODS: A Medline, Embase® and Opengrey libraries search was conducted from 2004 to February 2021, using the PICO model: older people, psychotropic drugs, inappropriate prescribing, and adverse drug events. Fixed-effects and random-effects meta-analysis were performed from 3 eligible studies using an inverse-variance method.
RESULTS: Of the 1943 originally identified abstracts, 106 met the inclusion criteria and 7 studies were included in this review. All were of good quality. The number of participants ranged from 318 to 383,150 older adults (54.5-74.4% women). Associations were found between PIPs use and decreased personal care activities of daily living (ADL), unplanned hospitalizations, falls and mortality. In the pooled analysis, association with falls was confirmed (1.23 [95%CI: 1.15;1.32]).
CONCLUSIONS: Participants of 65 years and older treated with PIPs were more at risk of adverse health outcomes than those using no PIPs, including greater risks of falls, functional disabilities, unplanned hospitalizations, and mortality. Results of the present systematic review and meta-analysis provide additional evidence for an appropriate and safe use of psychotropics in older adults.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
|---|---|
| Enthalten in: |
The journal of nutrition, health & aging - 28(2024), 4 vom: 10. Feb., Seite 100187 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Corvaisier, Mathieu [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Accidental falls |
|---|
| Anmerkungen: |
Date Revised 11.02.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1016/j.jnha.2024.100187 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368315290 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368315290 | ||
| 003 | DE-627 | ||
| 005 | 20240212232221.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240212s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jnha.2024.100187 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1289.xml |
| 035 | |a (DE-627)NLM368315290 | ||
| 035 | |a (NLM)38341965 | ||
| 035 | |a (PII)S1279-7707(24)00266-5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Corvaisier, Mathieu |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Preventable or potentially inappropriate psychotropics and adverse health outcomes in older adults |b systematic review and meta-analysis |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 11.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved. | ||
| 520 | |a OBJECTIVE: To systematically review and quantitatively synthetize evidence on the use of PIPs linked to adverse health outcomes in older adults | ||
| 520 | |a METHODS: A Medline, Embase® and Opengrey libraries search was conducted from 2004 to February 2021, using the PICO model: older people, psychotropic drugs, inappropriate prescribing, and adverse drug events. Fixed-effects and random-effects meta-analysis were performed from 3 eligible studies using an inverse-variance method | ||
| 520 | |a RESULTS: Of the 1943 originally identified abstracts, 106 met the inclusion criteria and 7 studies were included in this review. All were of good quality. The number of participants ranged from 318 to 383,150 older adults (54.5-74.4% women). Associations were found between PIPs use and decreased personal care activities of daily living (ADL), unplanned hospitalizations, falls and mortality. In the pooled analysis, association with falls was confirmed (1.23 [95%CI: 1.15;1.32]) | ||
| 520 | |a CONCLUSIONS: Participants of 65 years and older treated with PIPs were more at risk of adverse health outcomes than those using no PIPs, including greater risks of falls, functional disabilities, unplanned hospitalizations, and mortality. Results of the present systematic review and meta-analysis provide additional evidence for an appropriate and safe use of psychotropics in older adults | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Accidental falls | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Inappropriate | |
| 650 | 4 | |a Meta-analysis | |
| 650 | 4 | |a Psychotropics | |
| 700 | 1 | |a Brangier, Antoine |e verfasserin |4 aut | |
| 700 | 1 | |a Annweiler, Cédric |e verfasserin |4 aut | |
| 700 | 1 | |a Spiesser-Robelet, Laurence |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of nutrition, health & aging |d 1997 |g 28(2024), 4 vom: 10. Feb., Seite 100187 |w (DE-627)NLM107493446 |x 1760-4788 |7 nnns |
| 773 | 1 | 8 | |g volume:28 |g year:2024 |g number:4 |g day:10 |g month:02 |g pages:100187 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jnha.2024.100187 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 28 |j 2024 |e 4 |b 10 |c 02 |h 100187 | ||