The therapeutic perspective of NAD+ precursors in age-related diseases
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved..
Nicotinamide adenine dinucleotide (NAD+) is the fundamental molecule that performs numerous biological reactions and is crucial for maintaining cellular homeostasis. Studies have found that NAD+ decreases with age in certain tissues, and age-related NAD+ depletion affects physiological functions and contributes to various aging-related diseases. Supplementation of NAD+ precursor significantly elevates NAD+ levels in murine tissues, effectively mitigates metabolic syndrome, enhances cardiovascular health, protects against neurodegeneration, and boosts muscular strength. Despite the versatile therapeutic functions of NAD+ in animal studies, the efficacy of NAD+ precursors in clinical studies have been limited compared with that in the pre-clinical study. Clinical studies have demonstrated that NAD+ precursor treatment efficiently increases NAD+ levels in various tissues, though their clinical proficiency is insufficient to ameliorate the diseases. However, the latest studies regarding NAD+ precursors and their metabolism highlight the significant role of gut microbiota. The studies found that orally administered NAD+ intermediates interact with the gut microbiome. These findings provide compelling evidence for future trials to further explore the involvement of gut microbiota in NAD+ metabolism. Also, the reduced form of NAD+ precursor shows their potential to raise NAD+, though preclinical studies have yet to discover their efficacy. This review sheds light on NAD+ therapeutic efficiency in preclinical and clinical studies and the effect of the gut microbiota on NAD+ metabolism.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:702 |
---|---|
Enthalten in: |
Biochemical and biophysical research communications - 702(2024) vom: 02. Feb., Seite 149590 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Iqbal, Tooba [VerfasserIn] |
---|
Links: |
---|
Themen: |
0U46U6E8UK |
---|
Anmerkungen: |
Date Completed 26.02.2024 Date Revised 26.02.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.bbrc.2024.149590 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM368301729 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM368301729 | ||
003 | DE-627 | ||
005 | 20240229155228.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240211s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.bbrc.2024.149590 |2 doi | |
028 | 5 | 2 | |a pubmed24n1306.xml |
035 | |a (DE-627)NLM368301729 | ||
035 | |a (NLM)38340651 | ||
035 | |a (PII)S0006-291X(24)00125-6 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Iqbal, Tooba |e verfasserin |4 aut | |
245 | 1 | 4 | |a The therapeutic perspective of NAD+ precursors in age-related diseases |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 26.02.2024 | ||
500 | |a Date Revised 26.02.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. | ||
520 | |a Nicotinamide adenine dinucleotide (NAD+) is the fundamental molecule that performs numerous biological reactions and is crucial for maintaining cellular homeostasis. Studies have found that NAD+ decreases with age in certain tissues, and age-related NAD+ depletion affects physiological functions and contributes to various aging-related diseases. Supplementation of NAD+ precursor significantly elevates NAD+ levels in murine tissues, effectively mitigates metabolic syndrome, enhances cardiovascular health, protects against neurodegeneration, and boosts muscular strength. Despite the versatile therapeutic functions of NAD+ in animal studies, the efficacy of NAD+ precursors in clinical studies have been limited compared with that in the pre-clinical study. Clinical studies have demonstrated that NAD+ precursor treatment efficiently increases NAD+ levels in various tissues, though their clinical proficiency is insufficient to ameliorate the diseases. However, the latest studies regarding NAD+ precursors and their metabolism highlight the significant role of gut microbiota. The studies found that orally administered NAD+ intermediates interact with the gut microbiome. These findings provide compelling evidence for future trials to further explore the involvement of gut microbiota in NAD+ metabolism. Also, the reduced form of NAD+ precursor shows their potential to raise NAD+, though preclinical studies have yet to discover their efficacy. This review sheds light on NAD+ therapeutic efficiency in preclinical and clinical studies and the effect of the gut microbiota on NAD+ metabolism | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Aging | |
650 | 4 | |a Gut microbiota | |
650 | 4 | |a NAD(+) | |
650 | 4 | |a NAD(+) precursors | |
650 | 4 | |a Nicotinamide mononucleotide NMN | |
650 | 4 | |a Nicotinamide riboside NR | |
650 | 7 | |a NAD |2 NLM | |
650 | 7 | |a 0U46U6E8UK |2 NLM | |
650 | 7 | |a Niacinamide |2 NLM | |
650 | 7 | |a 25X51I8RD4 |2 NLM | |
650 | 7 | |a Nicotinamide Mononucleotide |2 NLM | |
650 | 7 | |a 1094-61-7 |2 NLM | |
700 | 1 | |a Nakagawa, Takashi |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Biochemical and biophysical research communications |d 1960 |g 702(2024) vom: 02. Feb., Seite 149590 |w (DE-627)NLM000000035 |x 1090-2104 |7 nnns |
773 | 1 | 8 | |g volume:702 |g year:2024 |g day:02 |g month:02 |g pages:149590 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.bbrc.2024.149590 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 702 |j 2024 |b 02 |c 02 |h 149590 |