Occult cancer in patients with unprovoked venous thromboembolism : A nested case-control study
© American Society for Clinical Pathology, 2024..
OBJECTIVES: Detecting occult cancer in patients with unprovoked venous thromboembolism (VTE) remains a significant challenge. Our objective was to investigate the potential predictive role of coagulation-related biomarkers in the diagnosis of occult malignancies.
METHODS: We conducted a nested case-control study with a 1-year prospective cohort of 214 patients with unprovoked VTE, with a focus on identifying occult cancer. At the time of VTE diagnosis, we measured various biomarkers, including soluble P-selectin (sP-selectin), dimerized plasmin fragment D (D-dimer), platelets, leukocytes, hemoglobin, total extracellular vesicles (EVs), EVs expressing tissue factor on their surface (TF+EVs), and EVs expressing P-selectin on their surface (Psel+EVs) in all participants.
RESULTS: We observed statistically significant increased levels of sP-selectin (P = .015) in patients with occult cancer. Despite an increase in Psel+EVs, TF+EVs, D-dimer, and platelets within this group, however, no significant differences were found. When sP-selectin exceeded 62 ng/mL and D-dimer surpassed 10,000 µg/L, the diagnosis of occult cancer demonstrated a specificity of up to 91% (95% CI, 79.9%-96.7%).
CONCLUSIONS: The combination of sP-selectin and D-dimer can be a valuable biomarker in detecting occult cancer in patients with unprovoked VTE. Further research is necessary to ascertain whether easily measurable biomarkers such as sP-selectin and D-dimer can effectively distinguish between patients who have VTE with and without hidden malignancies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
American journal of clinical pathology - (2024) vom: 10. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sánchez-López, Verónica [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer biomarkers |
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| Anmerkungen: |
Date Revised 10.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1093/ajcp/aqad178 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM368298507 |
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| 100 | 1 | |a Sánchez-López, Verónica |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Occult cancer in patients with unprovoked venous thromboembolism |b A nested case-control study |
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| 520 | |a © American Society for Clinical Pathology, 2024. | ||
| 520 | |a OBJECTIVES: Detecting occult cancer in patients with unprovoked venous thromboembolism (VTE) remains a significant challenge. Our objective was to investigate the potential predictive role of coagulation-related biomarkers in the diagnosis of occult malignancies | ||
| 520 | |a METHODS: We conducted a nested case-control study with a 1-year prospective cohort of 214 patients with unprovoked VTE, with a focus on identifying occult cancer. At the time of VTE diagnosis, we measured various biomarkers, including soluble P-selectin (sP-selectin), dimerized plasmin fragment D (D-dimer), platelets, leukocytes, hemoglobin, total extracellular vesicles (EVs), EVs expressing tissue factor on their surface (TF+EVs), and EVs expressing P-selectin on their surface (Psel+EVs) in all participants | ||
| 520 | |a RESULTS: We observed statistically significant increased levels of sP-selectin (P = .015) in patients with occult cancer. Despite an increase in Psel+EVs, TF+EVs, D-dimer, and platelets within this group, however, no significant differences were found. When sP-selectin exceeded 62 ng/mL and D-dimer surpassed 10,000 µg/L, the diagnosis of occult cancer demonstrated a specificity of up to 91% (95% CI, 79.9%-96.7%) | ||
| 520 | |a CONCLUSIONS: The combination of sP-selectin and D-dimer can be a valuable biomarker in detecting occult cancer in patients with unprovoked VTE. Further research is necessary to ascertain whether easily measurable biomarkers such as sP-selectin and D-dimer can effectively distinguish between patients who have VTE with and without hidden malignancies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a D-dimer | |
| 650 | 4 | |a P-selectin | |
| 650 | 4 | |a cancer biomarkers | |
| 650 | 4 | |a cell-derived microparticles | |
| 650 | 4 | |a extracellular vesicles | |
| 650 | 4 | |a occult cancer | |
| 700 | 1 | |a Marín-Romero, Samira |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrer-Galván, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Elías-Hernández, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Lobo Beristain, José Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Ballaz Quincoces, Aitor |e verfasserin |4 aut | |
| 700 | 1 | |a Jara-Palomares, Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez Martorell, Francisco Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Castro, María José |e verfasserin |4 aut | |
| 700 | 1 | |a Marín Hinojosa, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a López-Campos, José Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Otero-Candelera, Remedios |e verfasserin |4 aut | |
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