Current Approaches to Worsening Heart Failure : Pathophysiological and Molecular Insights
Worsening heart failure (WHF) is a severe and dynamic condition characterized by significant clinical and hemodynamic deterioration. It is characterized by worsening HF signs, symptoms and biomarkers, despite the achievement of an optimized medical therapy. It remains a significant challenge in cardiology, as it evolves into advanced and end-stage HF. The hyperactivation of the neurohormonal, adrenergic and renin-angiotensin-aldosterone system are well known pathophysiological pathways involved in HF. Several drugs have been developed to inhibit the latter, resulting in an improvement in life expectancy. Nevertheless, patients are exposed to a residual risk of adverse events, and the exploration of new molecular pathways and therapeutic targets is required. This review explores the current landscape of WHF, highlighting the complexities and factors contributing to this critical condition. Most recent medical advances have introduced cutting-edge pharmacological agents, such as guanylate cyclase stimulators and myosin activators. Regarding device-based therapies, invasive pulmonary pressure measurement and cardiac contractility modulation have emerged as promising tools to increase the quality of life and reduce hospitalizations due to HF exacerbations. Recent innovations in terms of WHF management emphasize the need for a multifaceted and patient-centric approach to address the complex HF syndrome.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
|---|---|
| Enthalten in: |
International journal of molecular sciences - 25(2024), 3 vom: 26. Jan. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
D'Amato, Andrea [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cardiac contractility modulation |
|---|
| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 14.02.2024 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.3390/ijms25031574 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368283461 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368283461 | ||
| 003 | DE-627 | ||
| 005 | 20240214233324.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240210s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijms25031574 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1293.xml |
| 035 | |a (DE-627)NLM368283461 | ||
| 035 | |a (NLM)38338853 | ||
| 035 | |a (PII)1574 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a D'Amato, Andrea |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Current Approaches to Worsening Heart Failure |b Pathophysiological and Molecular Insights |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 14.02.2024 | ||
| 500 | |a Date Revised 14.02.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Worsening heart failure (WHF) is a severe and dynamic condition characterized by significant clinical and hemodynamic deterioration. It is characterized by worsening HF signs, symptoms and biomarkers, despite the achievement of an optimized medical therapy. It remains a significant challenge in cardiology, as it evolves into advanced and end-stage HF. The hyperactivation of the neurohormonal, adrenergic and renin-angiotensin-aldosterone system are well known pathophysiological pathways involved in HF. Several drugs have been developed to inhibit the latter, resulting in an improvement in life expectancy. Nevertheless, patients are exposed to a residual risk of adverse events, and the exploration of new molecular pathways and therapeutic targets is required. This review explores the current landscape of WHF, highlighting the complexities and factors contributing to this critical condition. Most recent medical advances have introduced cutting-edge pharmacological agents, such as guanylate cyclase stimulators and myosin activators. Regarding device-based therapies, invasive pulmonary pressure measurement and cardiac contractility modulation have emerged as promising tools to increase the quality of life and reduce hospitalizations due to HF exacerbations. Recent innovations in terms of WHF management emphasize the need for a multifaceted and patient-centric approach to address the complex HF syndrome | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a SGLT2i | |
| 650 | 4 | |a cardiac contractility modulation | |
| 650 | 4 | |a levosimendan | |
| 650 | 4 | |a omecamtiv mecarbil | |
| 650 | 4 | |a vericiguat | |
| 650 | 4 | |a worsening heart failure | |
| 700 | 1 | |a Prosperi, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Severino, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Myftari, Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Labbro Francia, Aurora |e verfasserin |4 aut | |
| 700 | 1 | |a Cestiè, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Pierucci, Nicola |e verfasserin |4 aut | |
| 700 | 1 | |a Marek-Iannucci, Stefanie |e verfasserin |4 aut | |
| 700 | 1 | |a Mariani, Marco Valerio |e verfasserin |4 aut | |
| 700 | 1 | |a Germanò, Rosanna |e verfasserin |4 aut | |
| 700 | 1 | |a Fanisio, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Lavalle, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Maestrini, Viviana |e verfasserin |4 aut | |
| 700 | 1 | |a Badagliacca, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Mancone, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Fedele, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Vizza, Carmine Dario |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d 2008 |g 25(2024), 3 vom: 26. Jan. |w (DE-627)NLM185552161 |x 1422-0067 |7 nnns |
| 773 | 1 | 8 | |g volume:25 |g year:2024 |g number:3 |g day:26 |g month:01 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/ijms25031574 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 25 |j 2024 |e 3 |b 26 |c 01 | ||