Treatment of Equine Tarsus Long Medial Collateral Ligament Desmitis with Allogenic Synovial Membrane Mesenchymal Stem/Stromal Cells Enhanced by Umbilical Cord Mesenchymal Stem/Stromal Cell-Derived Conditioned Medium : Proof of Concept
Horses are high-performance athletes prone to sportive injuries such as tendonitis and desmitis. The formation of fibrous tissue in tendon repair remains a challenge to overcome. This impels regenerative medicine to develop innovative therapies that enhance regeneration, retrieving original tissue properties. Multipotent Mesenchymal Stem/Stromal Cells (MSCs) have been successfully used to develop therapeutic products, as they secrete a variety of bioactive molecules that play a pivotal role in tissue regeneration. These factors are released in culture media for producing a conditioned medium (CM). The aforementioned assumptions led to the formulation of equine synovial membrane MSCs (eSM-MSCs)-the cellular pool that naturally regenerates joint tissue-combined with a medium enriched in immunomodulatory factors (among other bioactive factors) produced by umbilical cord stroma-derived MSCs (eUC-MSCs) that naturally contribute to suppressing the immune rejection in the maternal-fetal barrier. A description of an equine sport horse diagnosed with acute tarsocrural desmitis and treated with this formulation is presented. Ultrasonographic ligament recovery occurred in a reduced time frame, reducing stoppage time and allowing for the horse's return to unrestricted competition after the completion of a physical rehabilitation program. This study focused on the description of the therapeutic formulation and potential in an equine desmitis treatment using the cells themselves and their secretomes.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
|---|---|
| Enthalten in: |
Animals : an open access journal from MDPI - 14(2024), 3 vom: 24. Jan. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Leal Reis, Inês [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Allogenic |
|---|
| Anmerkungen: |
Date Revised 12.02.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.3390/ani14030370 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368275019 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368275019 | ||
| 003 | DE-627 | ||
| 005 | 20240212232145.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240210s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ani14030370 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1289.xml |
| 035 | |a (DE-627)NLM368275019 | ||
| 035 | |a (NLM)38338013 | ||
| 035 | |a (PII)370 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Leal Reis, Inês |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Treatment of Equine Tarsus Long Medial Collateral Ligament Desmitis with Allogenic Synovial Membrane Mesenchymal Stem/Stromal Cells Enhanced by Umbilical Cord Mesenchymal Stem/Stromal Cell-Derived Conditioned Medium |b Proof of Concept |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 12.02.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Horses are high-performance athletes prone to sportive injuries such as tendonitis and desmitis. The formation of fibrous tissue in tendon repair remains a challenge to overcome. This impels regenerative medicine to develop innovative therapies that enhance regeneration, retrieving original tissue properties. Multipotent Mesenchymal Stem/Stromal Cells (MSCs) have been successfully used to develop therapeutic products, as they secrete a variety of bioactive molecules that play a pivotal role in tissue regeneration. These factors are released in culture media for producing a conditioned medium (CM). The aforementioned assumptions led to the formulation of equine synovial membrane MSCs (eSM-MSCs)-the cellular pool that naturally regenerates joint tissue-combined with a medium enriched in immunomodulatory factors (among other bioactive factors) produced by umbilical cord stroma-derived MSCs (eUC-MSCs) that naturally contribute to suppressing the immune rejection in the maternal-fetal barrier. A description of an equine sport horse diagnosed with acute tarsocrural desmitis and treated with this formulation is presented. Ultrasonographic ligament recovery occurred in a reduced time frame, reducing stoppage time and allowing for the horse's return to unrestricted competition after the completion of a physical rehabilitation program. This study focused on the description of the therapeutic formulation and potential in an equine desmitis treatment using the cells themselves and their secretomes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a MSC-based therapies | |
| 650 | 4 | |a allogenic | |
| 650 | 4 | |a conditioned medium | |
| 650 | 4 | |a equine | |
| 650 | 4 | |a ligament | |
| 650 | 4 | |a mesenchymal stem/stromal cells | |
| 650 | 4 | |a orthobiologic | |
| 650 | 4 | |a secretome | |
| 650 | 4 | |a synovial membrane | |
| 650 | 4 | |a umbilical cord | |
| 700 | 1 | |a Lopes, Bruna |e verfasserin |4 aut | |
| 700 | 1 | |a Sousa, Patrícia |e verfasserin |4 aut | |
| 700 | 1 | |a Sousa, Ana Catarina |e verfasserin |4 aut | |
| 700 | 1 | |a Branquinho, Mariana V |e verfasserin |4 aut | |
| 700 | 1 | |a Caseiro, Ana Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Rêma, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Briote, Inês |e verfasserin |4 aut | |
| 700 | 1 | |a Mendonça, Carla M |e verfasserin |4 aut | |
| 700 | 1 | |a Santos, Jorge Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Atayde, Luís M |e verfasserin |4 aut | |
| 700 | 1 | |a Alvites, Rui D |e verfasserin |4 aut | |
| 700 | 1 | |a Maurício, Ana Colette |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Animals : an open access journal from MDPI |d 2010 |g 14(2024), 3 vom: 24. Jan. |w (DE-627)NLM241007941 |x 2076-2615 |7 nnns |
| 773 | 1 | 8 | |g volume:14 |g year:2024 |g number:3 |g day:24 |g month:01 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/ani14030370 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 14 |j 2024 |e 3 |b 24 |c 01 | ||