Exposure to pollution during the first thousand days and telomere length regulation : A literature review
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved..
Telomere length (TL) is a biomarker for cellular senescence and TL erosion is predictive of the risk for age-related diseases. Despite being genetically determined at birth, TL may be susceptible to modifications through epigenetic mechanisms. Pollutant agents are considered one of the major threats to both human and planetary health. Their ability to cross the placental barrier and induce oxidative stress in fetal cells is particularly concerning and it may be associated with early TL erosion. In consideration of the timely relevance of this topic, we conducted a literature review on the impact of prenatal exposure to pollutant agents on newborn TL. The search yielded a total of 1099 records, of which only 32 met the inclusion criteria for the review. These criteria included the participation of human subjects, a longitudinal design or collection of longitudinal data, reporting of original TL data, and a focus on exposure to pollutant agents. The majority of the studies reported a significant inverse association between prenatal exposure to pollutant agents and TL. Furthermore, the second trimester of pregnancy emerged as a special sensitive period for the occurrence of pollutant agent-driven TL modifications. Sex differences were inconsistently reported across studies. This review contributes to highlighting biochemical pathways for the threats of environmental pollution to human health. Future research is warranted to further highlight potential buffering mechanisms.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:249 |
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| Enthalten in: |
Environmental research - 249(2024) vom: 07. Feb., Seite 118323 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pili, Miriam Paola [VerfasserIn] |
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| Links: |
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| Themen: |
Developmental programming |
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| Anmerkungen: |
Date Revised 11.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.envres.2024.118323 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368256499 |
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| 520 | |a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Telomere length (TL) is a biomarker for cellular senescence and TL erosion is predictive of the risk for age-related diseases. Despite being genetically determined at birth, TL may be susceptible to modifications through epigenetic mechanisms. Pollutant agents are considered one of the major threats to both human and planetary health. Their ability to cross the placental barrier and induce oxidative stress in fetal cells is particularly concerning and it may be associated with early TL erosion. In consideration of the timely relevance of this topic, we conducted a literature review on the impact of prenatal exposure to pollutant agents on newborn TL. The search yielded a total of 1099 records, of which only 32 met the inclusion criteria for the review. These criteria included the participation of human subjects, a longitudinal design or collection of longitudinal data, reporting of original TL data, and a focus on exposure to pollutant agents. The majority of the studies reported a significant inverse association between prenatal exposure to pollutant agents and TL. Furthermore, the second trimester of pregnancy emerged as a special sensitive period for the occurrence of pollutant agent-driven TL modifications. Sex differences were inconsistently reported across studies. This review contributes to highlighting biochemical pathways for the threats of environmental pollution to human health. Future research is warranted to further highlight potential buffering mechanisms | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Developmental programming | |
| 650 | 4 | |a First thousand days | |
| 650 | 4 | |a Infant | |
| 650 | 4 | |a Pollution | |
| 650 | 4 | |a Pregnancy | |
| 650 | 4 | |a Stress | |
| 650 | 4 | |a Telomere | |
| 700 | 1 | |a Cagliero, Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Panichi, Virginia |e verfasserin |4 aut | |
| 700 | 1 | |a Bordoni, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Pansarasa, Orietta |e verfasserin |4 aut | |
| 700 | 1 | |a Cremaschi, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Tonga, Elgin Bilge |e verfasserin |4 aut | |
| 700 | 1 | |a Cappelletti, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Provenzi, Livio |e verfasserin |4 aut | |
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