Automated analysis of choroidal thickness in patients with systemic lupus erithematosus treated with hydroxychloroquine

© 2024. The Author(s), under exclusive licence to Springer Nature B.V..

PURPOSE: To evaluate the influence of hydroxychloroquine (HCQ) in choroidal thickness (CT) in patients with systemic lupus erythematous (SLE), considering the possible impact of disease activity on the choroid.

METHODS: Cross-sectional study comparing three groups: two groups of SLE patients treated with HCQ without HCQ-retinopathy (32 eyes/32 patients with < 5 years of HCQ (group 1) and 44 eyes/44 patients with > 5 years of HCQ (group 2)), and an age-matched healthy control group of 46 eyes/46 patients (group 3). A complete ophthalmic examination was performed, including swept-source optical coherence tomography (SS-OCT) Triton (Topcon). Data were correlated to systemic disease activity parameters.

RESULTS: CT was thicker in group 1 compared to group 3 in central, nasal, and superior sectors, and to group 2 in inner superior and outer inferior sectors (p < 0.05). In the correlation analysis, disease activity and CT were inversely correlated in most sectors (p < 0.05). In the regression analysis, HCQ was related to thinner CT in temporal and inferior sectors and disease activity with variations in nasal sectors (p < 0.05).

CONCLUSIONS: In SLE patients, HCQ is correlated to decreased CT, especially in the inferior and temporal areas. The choroid shows different responses to SLE activity and HCQ, and some sectors may be more sensitive than others.

Medienart:

E-Artikel

Erscheinungsjahr:

2024

Erschienen:

2024

Enthalten in:

Zur Gesamtaufnahme - volume:44

Enthalten in:

International ophthalmology - 44(2024), 1 vom: 09. Feb., Seite 40

Sprache:

Englisch

Beteiligte Personen:

Arias-Peso, Borja [VerfasserIn]
Chacón González, María [VerfasserIn]
García-Navarro, Damián [VerfasserIn]
Ruiz Del Tiempo, María Pilar [VerfasserIn]
Pardiñas Barón, Nieves [VerfasserIn]
Sáez-Comet, Luis [VerfasserIn]
Ruiz-Moreno, Oscar [VerfasserIn]
Bartol-Puyal, Francisco [VerfasserIn]
Méndez-Martínez, Silvia [VerfasserIn]
Pablo Júlvez, Luis [VerfasserIn]

Links:

Volltext

Themen:

4QWG6N8QKH
Antirheumatic Agents
Biomarker
Choroid
Hydroxychloroquine
Journal Article
Retinotoxicity
Systemic lupus erythematosus

Anmerkungen:

Date Completed 14.02.2024

Date Revised 14.02.2024

published: Electronic

Citation Status MEDLINE

doi:

10.1007/s10792-024-03016-w

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM368243214