A Rare Case of High-Grade Spindle Cell Sarcoma of the Breast : A Case Report
© 2024 The Author(s). Published by S. Karger AG, Basel..
Introduction: Spindle cell sarcomas are rare breast lesions which are difficult to diagnose due to resemblance with other breast lesions. Histopathological examination and immunohistochemical staining are essential for diagnosis.
Case Presentation: We present a rare case of a 15-year-old female presenting with high-grade rapidly progressive spindle cell sarcoma of the breast, differentiated as phyllodes tumor, with axillary lymph node involvement. Her lesion, on the left breast, measured 16.9 × 10.1 × 13.7 cm. Histology revealed malignant neoplasm arranged in sheets and individual neoplastic cells with an epithelioid to spindled morphology with scant cytoplasm and irregular nuclear membranes. Immunohistochemistry showed weakly positive focal CD-99, and negative WT-1, Myogenin, Desmin, p63, Cytokeratin, Synaptophysin, and CD-34 markers. She was successfully managed with modified radical mastectomy and discharged with regular follow-up advised.
Conclusion: Spindle cell sarcomas have a very aggressive course and prompt diagnosis, and management is mandatory for better patient outcomes. Modified radical mastectomy is the mainstay of treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
|---|---|
| Enthalten in: |
Case reports in oncology - 17(2024), 1 vom: 27. Jan., Seite 217-224 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tharwani, Zoaib Habib [VerfasserIn] |
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| Links: |
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| Themen: |
Breast cancer |
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| Anmerkungen: |
Date Revised 10.02.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1159/000536125 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368231186 |
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| 245 | 1 | 2 | |a A Rare Case of High-Grade Spindle Cell Sarcoma of the Breast |b A Case Report |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2024 The Author(s). Published by S. Karger AG, Basel. | ||
| 520 | |a Introduction: Spindle cell sarcomas are rare breast lesions which are difficult to diagnose due to resemblance with other breast lesions. Histopathological examination and immunohistochemical staining are essential for diagnosis | ||
| 520 | |a Case Presentation: We present a rare case of a 15-year-old female presenting with high-grade rapidly progressive spindle cell sarcoma of the breast, differentiated as phyllodes tumor, with axillary lymph node involvement. Her lesion, on the left breast, measured 16.9 × 10.1 × 13.7 cm. Histology revealed malignant neoplasm arranged in sheets and individual neoplastic cells with an epithelioid to spindled morphology with scant cytoplasm and irregular nuclear membranes. Immunohistochemistry showed weakly positive focal CD-99, and negative WT-1, Myogenin, Desmin, p63, Cytokeratin, Synaptophysin, and CD-34 markers. She was successfully managed with modified radical mastectomy and discharged with regular follow-up advised | ||
| 520 | |a Conclusion: Spindle cell sarcomas have a very aggressive course and prompt diagnosis, and management is mandatory for better patient outcomes. Modified radical mastectomy is the mainstay of treatment | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Breast cancer | |
| 650 | 4 | |a Case report | |
| 650 | 4 | |a Phyllodes tumor | |
| 650 | 4 | |a Spindle cell carcinoma | |
| 700 | 1 | |a Habib, Zehra |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmed, Yumna |e verfasserin |4 aut | |
| 700 | 1 | |a Ishrat, Samreena |e verfasserin |4 aut | |
| 700 | 1 | |a Nashwan, Abdulqadir J |e verfasserin |4 aut | |
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