Skeletal Muscle Quality Assessment in Patients With Cardiac Disease Associated With Type 2 Diabetes Mellitus : A Pilot Study
Copyright © 2024, Takahashi et al..
Background Type 2 diabetes mellitus (T2DM) is associated with changes in skeletal muscle quantity and quality, such as increased ectopic fat. Cardiac rehabilitation (CR) aims to improve the exercise capacity and muscle strength. This study aimed to determine the relationship between qualitative changes in the skeletal muscles and exercise function in patients with and without diabetes mellitus. Methods The study included patients with cardiovascular diseases who entered CR. Of 72 CR patients (68.1±9.0 years) who underwent a cardiopulmonary exercise test and skeletal muscle assessment at discharge, 15 patients with T2DM and 15 without DM were selected using propensity score matching by age and gender. Results No significant differences in the skeletal muscle echo intensity (EI) (T2DM: 58.4, Non-DM: 53.4, p=0.32), skeletal muscle index (T2DM: 7.5 kg/m2, Non-DM: 7.2 kg/m2, p=0.36), or the weight-bearing index (WBI)(T2DM: 0.44, Non-DM: 0.50, p=0.35) existed between the two groups. The phase angle (PhA) (T2DM: 3.67°, Non-DM: 4.49°, p<0.05) and peak oxygen uptake (T2DM: 12.3 mL/kg/min, Non-DM: 14.8 mL/kg/min, p<0.05) were significantly lower in the T2DM group. PhA values showed a significant correlation with the WBI, a parameter of lower limb muscle strength (r=0.50, p<0.05). Conclusion The coexistence of cardiovascular disease and T2DM resulted in a decrease in the PhA, indicating a qualitative decrease in skeletal muscle mass. The PhA is also associated with lower limb muscle strength.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Cureus - 16(2024), 1 vom: 13. Jan., Seite e51897 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Takahashi, Momo [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiac rehabilitation |
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| Anmerkungen: |
Date Revised 10.02.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.7759/cureus.51897 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368229483 |
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| 520 | |a Copyright © 2024, Takahashi et al. | ||
| 520 | |a Background Type 2 diabetes mellitus (T2DM) is associated with changes in skeletal muscle quantity and quality, such as increased ectopic fat. Cardiac rehabilitation (CR) aims to improve the exercise capacity and muscle strength. This study aimed to determine the relationship between qualitative changes in the skeletal muscles and exercise function in patients with and without diabetes mellitus. Methods The study included patients with cardiovascular diseases who entered CR. Of 72 CR patients (68.1±9.0 years) who underwent a cardiopulmonary exercise test and skeletal muscle assessment at discharge, 15 patients with T2DM and 15 without DM were selected using propensity score matching by age and gender. Results No significant differences in the skeletal muscle echo intensity (EI) (T2DM: 58.4, Non-DM: 53.4, p=0.32), skeletal muscle index (T2DM: 7.5 kg/m2, Non-DM: 7.2 kg/m2, p=0.36), or the weight-bearing index (WBI)(T2DM: 0.44, Non-DM: 0.50, p=0.35) existed between the two groups. The phase angle (PhA) (T2DM: 3.67°, Non-DM: 4.49°, p<0.05) and peak oxygen uptake (T2DM: 12.3 mL/kg/min, Non-DM: 14.8 mL/kg/min, p<0.05) were significantly lower in the T2DM group. PhA values showed a significant correlation with the WBI, a parameter of lower limb muscle strength (r=0.50, p<0.05). Conclusion The coexistence of cardiovascular disease and T2DM resulted in a decrease in the PhA, indicating a qualitative decrease in skeletal muscle mass. The PhA is also associated with lower limb muscle strength | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a cardiac rehabilitation | |
| 650 | 4 | |a echo intensity | |
| 650 | 4 | |a peak oxygen uptake | |
| 650 | 4 | |a phase angle | |
| 650 | 4 | |a skeletal muscle quality | |
| 650 | 4 | |a type 2 diabetes mellitus | |
| 650 | 4 | |a weight-bearing index | |
| 700 | 1 | |a Tamura, Yuma |e verfasserin |4 aut | |
| 700 | 1 | |a Tsurumi, Tomoki |e verfasserin |4 aut | |
| 700 | 1 | |a Terashima, Masato |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Harunori |e verfasserin |4 aut | |
| 700 | 1 | |a Tamiya, Hajime |e verfasserin |4 aut | |
| 700 | 1 | |a Furuya, Tomoki |e verfasserin |4 aut | |
| 700 | 1 | |a Nakatani, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Otani, Naoyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Yasu, Takanori |e verfasserin |4 aut | |
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