Effects of fish oil on ethanol-induced gastric ulcer in rats : inflammatory responses and oxidative stress
Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc..
Background: The prevalence of peptic ulcers is increasing due to lifestyle changes and harmful diets.
Objective: The aim of this study was to investigate the effect of fish oil (FO) on gastric ulcers induced by ethanol in rats.
Methods: The pharmacological efficacy of FO with doses of 5 and 10 mg/kg investigated using the gastric ulcer index, the acidity of gastric secretions, pro-inflammatory cytokine assessment, and oxidative stress examination.
Results: Ethanol-induced gastric ulcer improves with FO 5 or 10 mg/kg pretreatment (P<0.05). FO did have acid-neutralizing activity. FO also increased the levels of glutathione and catalase and decreased the malondialdehyde levels (P<0.05). Moreover, FO reduced the levels of tumour necrosis factor alpha (TNF-α) interleukin-6 (IL-6), through downregulation of nuclear factor kappa B (NF-κB) (P<0.05). Pretreatment with FO attenuates ethanol-induced gastric ulceration.
Conclusion: The observed effects may be due to the role of FO in regulating gastric secretions, changes in the expression of NF-κB, and changes in the levels of oxidative stress factors.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:86 |
|---|---|
| Enthalten in: |
Annals of medicine and surgery (2012) - 86(2024), 2 vom: 05. Feb., Seite 819-825 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Taheri Mirghaed, Mahtab [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 10.02.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1097/MS9.0000000000001550 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368228002 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368228002 | ||
| 003 | DE-627 | ||
| 005 | 20240210233401.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240209s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/MS9.0000000000001550 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1287.xml |
| 035 | |a (DE-627)NLM368228002 | ||
| 035 | |a (NLM)38333309 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Taheri Mirghaed, Mahtab |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of fish oil on ethanol-induced gastric ulcer in rats |b inflammatory responses and oxidative stress |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 10.02.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. | ||
| 520 | |a Background: The prevalence of peptic ulcers is increasing due to lifestyle changes and harmful diets | ||
| 520 | |a Objective: The aim of this study was to investigate the effect of fish oil (FO) on gastric ulcers induced by ethanol in rats | ||
| 520 | |a Methods: The pharmacological efficacy of FO with doses of 5 and 10 mg/kg investigated using the gastric ulcer index, the acidity of gastric secretions, pro-inflammatory cytokine assessment, and oxidative stress examination | ||
| 520 | |a Results: Ethanol-induced gastric ulcer improves with FO 5 or 10 mg/kg pretreatment (P<0.05). FO did have acid-neutralizing activity. FO also increased the levels of glutathione and catalase and decreased the malondialdehyde levels (P<0.05). Moreover, FO reduced the levels of tumour necrosis factor alpha (TNF-α) interleukin-6 (IL-6), through downregulation of nuclear factor kappa B (NF-κB) (P<0.05). Pretreatment with FO attenuates ethanol-induced gastric ulceration | ||
| 520 | |a Conclusion: The observed effects may be due to the role of FO in regulating gastric secretions, changes in the expression of NF-κB, and changes in the levels of oxidative stress factors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ethanol | |
| 650 | 4 | |a fish oil | |
| 650 | 4 | |a gastric ulcer | |
| 700 | 1 | |a Ghasemian, Seyedeh Ommolbanin |e verfasserin |4 aut | |
| 700 | 1 | |a Mousavi Nasab, Seyyed Fazlollah |e verfasserin |4 aut | |
| 700 | 1 | |a Rahimi, Kaveh |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of medicine and surgery (2012) |d 2012 |g 86(2024), 2 vom: 05. Feb., Seite 819-825 |w (DE-627)NLM245154396 |x 2049-0801 |7 nnns |
| 773 | 1 | 8 | |g volume:86 |g year:2024 |g number:2 |g day:05 |g month:02 |g pages:819-825 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1097/MS9.0000000000001550 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 86 |j 2024 |e 2 |b 05 |c 02 |h 819-825 | ||