Participation of B cell in immunotherapy of cancer
Copyright © 2024 Elsevier GmbH. All rights reserved..
Even though their effector roles extend beyond conventional humoral immunity, B and plasma cells may exhibit antitumor effects through antibody-dependent cell cytotoxicity (ADCC) and activation of the complement cascade. Depending on whether they are positioned in immature or mature compartments termed tertiary lymphoid structures (TLS), which include T cells, B cells are believed to play numerous functions in modulating the immune system's capacity to destroy cancer cells. These formations represent a process of lymphoid neogenesis that takes place in peripheral tissues in response to prolonged exposure to inflammatory signals. Activated in the germinal centres of tertiary lymphoid structures, B cells may directly present tumor-associated antigens to T cells, make antibodies that enhance antigen presentation to T cells, or kill tumour cells, resulting in a favourable therapeutic effect. Immune complexes may also enhance inflammation, angiogenesis, and immunosuppression via the activation of macrophages and complement, resulting in detrimental effects. The functional variety of B-cell subsets includes professional antigen-presenting cells, regulatory cells, memory populations, and plasma cells that produce antibodies. Importantly, antibodies may independently generate innate immune responses and the cancer immunity cycle. B cells and B-cell-mediated antibody responses constitute the largely underestimated second arm of the adaptive immune system and unquestionably need more consideration in cancer. This article reviews the known roles of B lymphocytes in the tumour microenvironment, their contribution to anticancer activity of immunotherapies, and their significance in overall survival of cancer patients. In addition to producing antibodies, B cells regulate the immune system and serve as effective antigen-presenting cells.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:255 |
---|---|
Enthalten in: |
Pathology, research and practice - 255(2024) vom: 30. März, Seite 155169 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Chandnani, Nikhil [VerfasserIn] |
---|
Links: |
---|
Themen: |
ADCC |
---|
Anmerkungen: |
Date Completed 11.03.2024 Date Revised 11.03.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.prp.2024.155169 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM368201066 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM368201066 | ||
003 | DE-627 | ||
005 | 20240311232244.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240209s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.prp.2024.155169 |2 doi | |
028 | 5 | 2 | |a pubmed24n1323.xml |
035 | |a (DE-627)NLM368201066 | ||
035 | |a (NLM)38330617 | ||
035 | |a (PII)S0344-0338(24)00080-3 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Chandnani, Nikhil |e verfasserin |4 aut | |
245 | 1 | 0 | |a Participation of B cell in immunotherapy of cancer |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 11.03.2024 | ||
500 | |a Date Revised 11.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2024 Elsevier GmbH. All rights reserved. | ||
520 | |a Even though their effector roles extend beyond conventional humoral immunity, B and plasma cells may exhibit antitumor effects through antibody-dependent cell cytotoxicity (ADCC) and activation of the complement cascade. Depending on whether they are positioned in immature or mature compartments termed tertiary lymphoid structures (TLS), which include T cells, B cells are believed to play numerous functions in modulating the immune system's capacity to destroy cancer cells. These formations represent a process of lymphoid neogenesis that takes place in peripheral tissues in response to prolonged exposure to inflammatory signals. Activated in the germinal centres of tertiary lymphoid structures, B cells may directly present tumor-associated antigens to T cells, make antibodies that enhance antigen presentation to T cells, or kill tumour cells, resulting in a favourable therapeutic effect. Immune complexes may also enhance inflammation, angiogenesis, and immunosuppression via the activation of macrophages and complement, resulting in detrimental effects. The functional variety of B-cell subsets includes professional antigen-presenting cells, regulatory cells, memory populations, and plasma cells that produce antibodies. Importantly, antibodies may independently generate innate immune responses and the cancer immunity cycle. B cells and B-cell-mediated antibody responses constitute the largely underestimated second arm of the adaptive immune system and unquestionably need more consideration in cancer. This article reviews the known roles of B lymphocytes in the tumour microenvironment, their contribution to anticancer activity of immunotherapies, and their significance in overall survival of cancer patients. In addition to producing antibodies, B cells regulate the immune system and serve as effective antigen-presenting cells | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a ADCC | |
650 | 4 | |a APC | |
650 | 4 | |a B cell | |
650 | 4 | |a Humoral immunity | |
650 | 4 | |a Tumour cells | |
650 | 7 | |a Antibodies |2 NLM | |
700 | 1 | |a Gupta, Ishika |e verfasserin |4 aut | |
700 | 1 | |a Mandal, Ayush |e verfasserin |4 aut | |
700 | 1 | |a Sarkar, Koustav |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Pathology, research and practice |d 1980 |g 255(2024) vom: 30. März, Seite 155169 |w (DE-627)NLM000326879 |x 1618-0631 |7 nnns |
773 | 1 | 8 | |g volume:255 |g year:2024 |g day:30 |g month:03 |g pages:155169 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.prp.2024.155169 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 255 |j 2024 |b 30 |c 03 |h 155169 |