Selective Laser Melting of the Porous Ta Scaffold with Mg-Doped Calcium Phosphate Coating for Orthopedic Applications
Addressing the repair of large-scale bone defects has become a hot research topic within the field of orthopedics. This study assessed the feasibility and effectiveness of using porous tantalum scaffolds to treat such defects. These scaffolds, manufactured using the selective laser melting (SLM) technology, possessed biomechanical properties compatible with natural bone tissue. To enhance the osteogenesis bioactivity of these porous Ta scaffolds, we applied calcium phosphate (CaP) and magnesium-doped calcium phosphate (Mg-CaP) coatings to the surface of SLM Ta scaffolds through a hydrothermal method. These degradable coatings released calcium and magnesium ions, demonstrating osteogenic bioactivity. Experimental results indicated that the Mg-CaP group exhibited biocompatibility comparable to that of the Ta group in vivo and in vitro. In terms of osteogenesis, both the CaP group and the Mg-CaP group showed improved outcomes compared to the control group, with the Mg-CaP group demonstrating superior performance. Therefore, both CaP and magnesium-CaP coatings can significantly enhance the osseointegration of three-dimensional-printed porous Ta, thereby increasing the surface bioactivity. Overall, the present study introduces an innovative approach for the biofunctionalization of SLM porous Ta, aiming to enhance its suitability as a bone implant material.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
|---|---|
| Enthalten in: |
ACS biomaterials science & engineering - 10(2024), 3 vom: 11. März, Seite 1435-1447 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Xu, Jianfeng [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
6424HBN274 |
|---|
| Anmerkungen: |
Date Completed 12.03.2024 Date Revised 12.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1021/acsbiomaterials.3c01503 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM36819695X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM36819695X | ||
| 003 | DE-627 | ||
| 005 | 20240312233752.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240209s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1021/acsbiomaterials.3c01503 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1324.xml |
| 035 | |a (DE-627)NLM36819695X | ||
| 035 | |a (NLM)38330203 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Xu, Jianfeng |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Selective Laser Melting of the Porous Ta Scaffold with Mg-Doped Calcium Phosphate Coating for Orthopedic Applications |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 12.03.2024 | ||
| 500 | |a Date Revised 12.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Addressing the repair of large-scale bone defects has become a hot research topic within the field of orthopedics. This study assessed the feasibility and effectiveness of using porous tantalum scaffolds to treat such defects. These scaffolds, manufactured using the selective laser melting (SLM) technology, possessed biomechanical properties compatible with natural bone tissue. To enhance the osteogenesis bioactivity of these porous Ta scaffolds, we applied calcium phosphate (CaP) and magnesium-doped calcium phosphate (Mg-CaP) coatings to the surface of SLM Ta scaffolds through a hydrothermal method. These degradable coatings released calcium and magnesium ions, demonstrating osteogenic bioactivity. Experimental results indicated that the Mg-CaP group exhibited biocompatibility comparable to that of the Ta group in vivo and in vitro. In terms of osteogenesis, both the CaP group and the Mg-CaP group showed improved outcomes compared to the control group, with the Mg-CaP group demonstrating superior performance. Therefore, both CaP and magnesium-CaP coatings can significantly enhance the osseointegration of three-dimensional-printed porous Ta, thereby increasing the surface bioactivity. Overall, the present study introduces an innovative approach for the biofunctionalization of SLM porous Ta, aiming to enhance its suitability as a bone implant material | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CaP coating | |
| 650 | 4 | |a Mg2+ | |
| 650 | 4 | |a hydrothermal treatment | |
| 650 | 4 | |a osteogenesis | |
| 650 | 4 | |a porous Ta | |
| 650 | 7 | |a Magnesium |2 NLM | |
| 650 | 7 | |a I38ZP9992A |2 NLM | |
| 650 | 7 | |a Tantalum |2 NLM | |
| 650 | 7 | |a 6424HBN274 |2 NLM | |
| 650 | 7 | |a Titanium |2 NLM | |
| 650 | 7 | |a D1JT611TNE |2 NLM | |
| 650 | 7 | |a calcium phosphate |2 NLM | |
| 650 | 7 | |a 97Z1WI3NDX |2 NLM | |
| 650 | 7 | |a Calcium Phosphates |2 NLM | |
| 700 | 1 | |a Wu, Di |e verfasserin |4 aut | |
| 700 | 1 | |a Ge, Bing |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Maoyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Haiyu |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Weidan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Yi, Pinqiao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Haiyao |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Liqun |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Lingpeng |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Junlei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Dewei |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t ACS biomaterials science & engineering |d 2015 |g 10(2024), 3 vom: 11. März, Seite 1435-1447 |w (DE-627)NLM249114623 |x 2373-9878 |7 nnns |
| 773 | 1 | 8 | |g volume:10 |g year:2024 |g number:3 |g day:11 |g month:03 |g pages:1435-1447 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1021/acsbiomaterials.3c01503 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 10 |j 2024 |e 3 |b 11 |c 03 |h 1435-1447 | ||