Synthesis of Substituted Pentafluorosulfanylpyrazoles Under Flow Conditions
The development of flow conditions for the synthesis of pentafluorosulfanylpyrazoles is reported. A range of alkyl- and aryl-substituted SF5-alkynes were used in combination with different diazoacetates for this transformation. The corresponding substituted SF5-pyrazoles were obtained in up to 90% yield (average of 74% for 21 examples) as a mixture of isomers (up to 73:27 ratio). Synthetic transformations starting from an SF5-containing pyrazole were also demonstrated.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
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| Enthalten in: |
The Journal of organic chemistry - 89(2024), 5 vom: 01. März, Seite 3552-3562 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Paquin, Pascal [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Revised 01.03.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.joc.3c02295 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368194671 |
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| 520 | |a The development of flow conditions for the synthesis of pentafluorosulfanylpyrazoles is reported. A range of alkyl- and aryl-substituted SF5-alkynes were used in combination with different diazoacetates for this transformation. The corresponding substituted SF5-pyrazoles were obtained in up to 90% yield (average of 74% for 21 examples) as a mixture of isomers (up to 73:27 ratio). Synthetic transformations starting from an SF5-containing pyrazole were also demonstrated | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Bélanger-Chabot, Guillaume |e verfasserin |4 aut | |
| 700 | 1 | |a Paquin, Jean-François |e verfasserin |4 aut | |
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