Chemoembolization versus radiofrequency ablation for single small (≤ 3 cm) hepatocellular carcinoma : a propensity score matching analysis
© 2024. The Author(s), under exclusive licence to European Society of Radiology..
OBJECTIVES: To compare the efficacy of transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for patients with single small (≤ 3 cm) hepatocellular carcinoma (HCC) and preserved liver function (Child-Pugh class A).
MATERIALS AND METHODS: The clinical features of treatment-naïve patients who underwent TACE and RFA as first-line treatment were balanced through propensity score matching (PSM). The primary endpoint was overall survival (OS), and the secondary endpoints were local tumor recurrence (LTR) and recurrence-free survival (RFS).
RESULTS: The analysis included 440 patients who received TACE, and 430 patients who received RFA. After PSM adjustment (323 pairs), the 5- and 10-year OS rates were 81% and 61%, respectively, in patients who underwent RFA, and 77% and 51%, respectively, for patients who underwent TACE (p = 0.021). Subgroup analyses showed that OS, LTR, and RFS were homogeneously better in the RFA group.
CONCLUSION: RFA was associated with better survival outcomes than TACE in patients with single small HCC and preserved liver function.
CLINICAL RELEVANCE STATEMENT: This large-scale comparative study provides evidence that radiofrequency ablation has a better overall survival rate than chemoembolization for small (≤ 3 cm) hepatocellular carcinomas.
KEY POINTS: • The relative effectiveness of transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for early HCC is unclear. • Overall survival rate was significantly higher in the RFA group. • The effects of RFA on overall survival, local tumor recurrence, and recurrence-free survival were homogeneously better in all subgroups.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
European radiology - (2024) vom: 08. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kim, Gun Ha [VerfasserIn] |
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| Links: |
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| Themen: |
Carcinoma (hepatocellular) |
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| Anmerkungen: |
Date Revised 08.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1007/s00330-024-10634-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368187292 |
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| 041 | |a eng | ||
| 100 | 1 | |a Kim, Gun Ha |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chemoembolization versus radiofrequency ablation for single small (≤ 3 cm) hepatocellular carcinoma |b a propensity score matching analysis |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Revised 08.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2024. The Author(s), under exclusive licence to European Society of Radiology. | ||
| 520 | |a OBJECTIVES: To compare the efficacy of transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for patients with single small (≤ 3 cm) hepatocellular carcinoma (HCC) and preserved liver function (Child-Pugh class A) | ||
| 520 | |a MATERIALS AND METHODS: The clinical features of treatment-naïve patients who underwent TACE and RFA as first-line treatment were balanced through propensity score matching (PSM). The primary endpoint was overall survival (OS), and the secondary endpoints were local tumor recurrence (LTR) and recurrence-free survival (RFS) | ||
| 520 | |a RESULTS: The analysis included 440 patients who received TACE, and 430 patients who received RFA. After PSM adjustment (323 pairs), the 5- and 10-year OS rates were 81% and 61%, respectively, in patients who underwent RFA, and 77% and 51%, respectively, for patients who underwent TACE (p = 0.021). Subgroup analyses showed that OS, LTR, and RFS were homogeneously better in the RFA group | ||
| 520 | |a CONCLUSION: RFA was associated with better survival outcomes than TACE in patients with single small HCC and preserved liver function | ||
| 520 | |a CLINICAL RELEVANCE STATEMENT: This large-scale comparative study provides evidence that radiofrequency ablation has a better overall survival rate than chemoembolization for small (≤ 3 cm) hepatocellular carcinomas | ||
| 520 | |a KEY POINTS: • The relative effectiveness of transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for early HCC is unclear. • Overall survival rate was significantly higher in the RFA group. • The effects of RFA on overall survival, local tumor recurrence, and recurrence-free survival were homogeneously better in all subgroups | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Carcinoma (hepatocellular) | |
| 650 | 4 | |a Chemoembolization (therapeutic) | |
| 650 | 4 | |a Propensity score | |
| 650 | 4 | |a Radiofrequency ablation | |
| 650 | 4 | |a Treatment outcome | |
| 700 | 1 | |a Kim, Jin Hyoung |e verfasserin |4 aut | |
| 700 | 1 | |a Shim, Ju Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, So Yeon |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Pyeong Hwa |e verfasserin |4 aut | |
| 700 | 1 | |a Ko, Heung-Kyu |e verfasserin |4 aut | |
| 700 | 1 | |a Gwon, Dong Il |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Ji Hoon |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, So Jung |e verfasserin |4 aut | |
| 700 | 1 | |a Chu, Hee Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Won, Hyung Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Yong Moon |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Nayoung |e verfasserin |4 aut | |
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