Chromosome level genome assembly of the Etruscan shrew Suncus etruscus
© 2024. The Author(s)..
Suncus etruscus is one of the world's smallest mammals, with an average body mass of about 2 grams. The Etruscan shrew's small body is accompanied by a very high energy demand and numerous metabolic adaptations. Here we report a chromosome-level genome assembly using PacBio long read sequencing, 10X Genomics linked short reads, optical mapping, and Hi-C linked reads. The assembly is partially phased, with the 2.472 Gbp primary pseudohaplotype and 1.515 Gbp alternate. We manually curated the primary assembly and identified 22 chromosomes, including X and Y sex chromosomes. The NCBI genome annotation pipeline identified 39,091 genes, 19,819 of them protein-coding. We also identified segmental duplications, inferred GO term annotations, and computed orthologs of human and mouse genes. This reference-quality genome will be an important resource for research on mammalian development, metabolism, and body size control.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Scientific data - 11(2024), 1 vom: 07. Feb., Seite 176 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bukhman, Yury V [VerfasserIn] |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 18.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41597-024-03011-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM368155684 |
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| 520 | |a © 2024. The Author(s). | ||
| 520 | |a Suncus etruscus is one of the world's smallest mammals, with an average body mass of about 2 grams. The Etruscan shrew's small body is accompanied by a very high energy demand and numerous metabolic adaptations. Here we report a chromosome-level genome assembly using PacBio long read sequencing, 10X Genomics linked short reads, optical mapping, and Hi-C linked reads. The assembly is partially phased, with the 2.472 Gbp primary pseudohaplotype and 1.515 Gbp alternate. We manually curated the primary assembly and identified 22 chromosomes, including X and Y sex chromosomes. The NCBI genome annotation pipeline identified 39,091 genes, 19,819 of them protein-coding. We also identified segmental duplications, inferred GO term annotations, and computed orthologs of human and mouse genes. This reference-quality genome will be an important resource for research on mammalian development, metabolism, and body size control | ||
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| 700 | 1 | |a Chu, Li-Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Abueg, Linelle |e verfasserin |4 aut | |
| 700 | 1 | |a Antosiewicz-Bourget, Jessica |e verfasserin |4 aut | |
| 700 | 1 | |a Balacco, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Brecht, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Dinatale, Erica |e verfasserin |4 aut | |
| 700 | 1 | |a Fedrigo, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Formenti, Giulio |e verfasserin |4 aut | |
| 700 | 1 | |a Fungtammasan, Arkarachai |e verfasserin |4 aut | |
| 700 | 1 | |a Giri, Swagarika Jaharlal |e verfasserin |4 aut | |
| 700 | 1 | |a Hiller, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Howe, Kerstin |e verfasserin |4 aut | |
| 700 | 1 | |a Kihara, Daisuke |e verfasserin |4 aut | |
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| 700 | 1 | |a Rabbani, Keon |e verfasserin |4 aut | |
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