Concurrent Clade I and Clade II Monkeypox Virus Circulation, Cameroon, 1979-2022
During 1979-2022, Cameroon recorded 32 laboratory-confirmed mpox cases among 137 suspected mpox cases identified by the national surveillance network. The highest positivity rate occurred in 2022, indicating potential mpox re-emergence in Cameroon. Both clade I (n = 12) and clade II (n = 18) monkeypox virus (MPXV) were reported, a unique feature of mpox in Cameroon. The overall case-fatality ratio of 2.2% was associated with clade II. We found mpox occurred only in the forested southern part of the country, and MPXV phylogeographic structure revealed a clear geographic separation among concurrent circulating clades. Clade I originated from eastern regions close to neighboring mpox-endemic countries in Central Africa; clade II was prevalent in western regions close to West Africa. Our findings suggest that MPXV re-emerged after a 30-year lapse and might arise from different viral reservoirs unique to ecosystems in eastern and western rainforests of Cameroon.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Emerging infectious diseases - 30(2024), 3 vom: 27. März, Seite 432-443 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Djuicy, Delia D [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 26.02.2024 Date Revised 02.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.3201/eid3003.230861 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368146073 |
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| 520 | |a During 1979-2022, Cameroon recorded 32 laboratory-confirmed mpox cases among 137 suspected mpox cases identified by the national surveillance network. The highest positivity rate occurred in 2022, indicating potential mpox re-emergence in Cameroon. Both clade I (n = 12) and clade II (n = 18) monkeypox virus (MPXV) were reported, a unique feature of mpox in Cameroon. The overall case-fatality ratio of 2.2% was associated with clade II. We found mpox occurred only in the forested southern part of the country, and MPXV phylogeographic structure revealed a clear geographic separation among concurrent circulating clades. Clade I originated from eastern regions close to neighboring mpox-endemic countries in Central Africa; clade II was prevalent in western regions close to West Africa. Our findings suggest that MPXV re-emerged after a 30-year lapse and might arise from different viral reservoirs unique to ecosystems in eastern and western rainforests of Cameroon | ||
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| 700 | 1 | |a Yonga, Martial G |e verfasserin |4 aut | |
| 700 | 1 | |a Tchatchueng-Mbougua, Jules B |e verfasserin |4 aut | |
| 700 | 1 | |a Essima, Gael D |e verfasserin |4 aut | |
| 700 | 1 | |a Esso, Linda |e verfasserin |4 aut | |
| 700 | 1 | |a Nguidjol, Inès M E |e verfasserin |4 aut | |
| 700 | 1 | |a Metomb, Steve F |e verfasserin |4 aut | |
| 700 | 1 | |a Chebo, Cornelius |e verfasserin |4 aut | |
| 700 | 1 | |a Agwe, Samuel M |e verfasserin |4 aut | |
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| 700 | 1 | |a Njouom, Richard |e verfasserin |4 aut | |
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