Comprehensive characterization of small noncoding RNA profiles in hypoxia-induced pulmonary hypertension (HPH) rat tissues
© 2024 The Authors..
Hypoxia-induced pulmonary hypertension (HPH) is a fatal cardiovascular disease characterized by an elevation in pulmonary artery pressure, resulting in right ventricular dysfunction and eventual heart failure. Exploring the pathogenesis of HPH is crucial, and small noncoding RNAs (sncRNAs) are gaining recognition as potential regulators of cellular responses to hypoxia. In this study, we conducted a comprehensive analysis of sncRNA profiles in eight tissues of male HPH rats using high-throughput sequencing. Our study unveiled several sncRNAs, with the brain, kidney, and spleen exhibiting the highest abundance of microRNA (miRNA), tRNA-derived small RNA (tDR), and small nucleolar RNA (snoRNA), respectively. Moreover, we identified numerous tissue-specific and hypoxia-responsive sncRNAs, particularly miRNAs and tDRs. Interestingly, we observed arm switching in miRNAs under hypoxic conditions and a significant increase in the abundance of 5' tRNA-halves among the total tDRs during hypoxia. Overall, our study provides a comprehensive characterization of the sncRNA profiles in HPH rats.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
iScience - 27(2024), 2 vom: 16. Feb., Seite 108815 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Jun [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiovascular medicine |
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| Anmerkungen: |
Date Revised 10.02.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.isci.2024.108815 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368121917 |
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| 520 | |a Hypoxia-induced pulmonary hypertension (HPH) is a fatal cardiovascular disease characterized by an elevation in pulmonary artery pressure, resulting in right ventricular dysfunction and eventual heart failure. Exploring the pathogenesis of HPH is crucial, and small noncoding RNAs (sncRNAs) are gaining recognition as potential regulators of cellular responses to hypoxia. In this study, we conducted a comprehensive analysis of sncRNA profiles in eight tissues of male HPH rats using high-throughput sequencing. Our study unveiled several sncRNAs, with the brain, kidney, and spleen exhibiting the highest abundance of microRNA (miRNA), tRNA-derived small RNA (tDR), and small nucleolar RNA (snoRNA), respectively. Moreover, we identified numerous tissue-specific and hypoxia-responsive sncRNAs, particularly miRNAs and tDRs. Interestingly, we observed arm switching in miRNAs under hypoxic conditions and a significant increase in the abundance of 5' tRNA-halves among the total tDRs during hypoxia. Overall, our study provides a comprehensive characterization of the sncRNA profiles in HPH rats | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cardiovascular medicine | |
| 650 | 4 | |a Model organism | |
| 650 | 4 | |a Transcriptomics | |
| 700 | 1 | |a Kuang, Jiahao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Shasha |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zixin |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Qianwen |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Shujin |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Gaohui |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Xinyang |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Jiayu |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Jinglin |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Jinyong |e verfasserin |4 aut | |
| 700 | 1 | |a Niu, Yanqin |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Kang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yunhui |e verfasserin |4 aut | |
| 700 | 1 | |a Gou, Deming |e verfasserin |4 aut | |
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