The Dynamic Model of the Active-Inactive Cell Interface
© 2024《四川大学学报（医学版）》编辑部 版权所有Copyright ©2024 Editorial Board of Journal of Sichuan University (Medical Sciences)..
Objective: To explore the morphodynamics of the active-inactive cell monolayer interfaces by using the active liquid crystal model.
Methods: A continuum mechanical model was established based on the active liquid crystal theory and the active-inactive cell monolayer interfaces were established by setting the activity difference of cell monolayers. The theoretical equations were solved numerically by the finite difference and the lattice Boltzmann method.
Results: The active-inactive cell interfaces displayed three typical morphologies, namely, flat interface, wavy interface, and finger-like interface. On the flat interfaces, the cells were oriented perpendicular to the interface, the -1/2 topological defects were clustered in the interfaces, and the interfaces were negatively charged. On the wavy interfaces, cells showed no obvious preference for orientation at the interfaces and the interfaces were neutrally charged. On the finger-like interfaces, cells were tangentially oriented at the interfaces, the +1/2 topological defects were collected at the interfaces, driving the growth of the finger-like structures, and the interfaces were positively charged.
Conclusion: The orientation of the cell alignment at the interface can significantly affect the morphologies of the active-inactive cell monolayer interfaces, which is closely associated with the dynamics of topological defects at the interfaces.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
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| Enthalten in: |
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition - 55(2024), 1 vom: 20. Jan., Seite 39-46 |
| Sprache: |
Chinesisch |
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| Weiterer Titel: |
活性-非活性细胞界面动力学模型 |
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| Beteiligte Personen: |
Zhang, Deqing [VerfasserIn] |
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| Links: |
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| Themen: |
Activity |
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| Anmerkungen: |
Date Completed 08.02.2024 Date Revised 10.02.2024 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.12182/20240160508 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368117316 |
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| 245 | 1 | 4 | |a The Dynamic Model of the Active-Inactive Cell Interface |
| 246 | 3 | 3 | |a 活性-非活性细胞界面动力学模型 |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2024《四川大学学报（医学版）》编辑部 版权所有Copyright ©2024 Editorial Board of Journal of Sichuan University (Medical Sciences). | ||
| 520 | |a Objective: To explore the morphodynamics of the active-inactive cell monolayer interfaces by using the active liquid crystal model | ||
| 520 | |a Methods: A continuum mechanical model was established based on the active liquid crystal theory and the active-inactive cell monolayer interfaces were established by setting the activity difference of cell monolayers. The theoretical equations were solved numerically by the finite difference and the lattice Boltzmann method | ||
| 520 | |a Results: The active-inactive cell interfaces displayed three typical morphologies, namely, flat interface, wavy interface, and finger-like interface. On the flat interfaces, the cells were oriented perpendicular to the interface, the -1/2 topological defects were clustered in the interfaces, and the interfaces were negatively charged. On the wavy interfaces, cells showed no obvious preference for orientation at the interfaces and the interfaces were neutrally charged. On the finger-like interfaces, cells were tangentially oriented at the interfaces, the +1/2 topological defects were collected at the interfaces, driving the growth of the finger-like structures, and the interfaces were positively charged | ||
| 520 | |a Conclusion: The orientation of the cell alignment at the interface can significantly affect the morphologies of the active-inactive cell monolayer interfaces, which is closely associated with the dynamics of topological defects at the interfaces | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Activity | |
| 650 | 4 | |a Cell interface | |
| 650 | 4 | |a Topological defect | |
| 700 | 1 | |a Zhang, Haoshun |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Bo |e verfasserin |4 aut | |
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