Long-acting anti-inflammatory injectable DEX-Gel with sustained release and self-healing properties regulates TH1/TH2 immune balance for minimally invasive treatment of allergic rhinitis
© 2024. The Author(s)..
BACKGROUND: Allergic rhinitis (AR) is a prevalent immune-related allergic disease, and corticosteroid nasal sprays serve as the primary treatment for this patient population. However, their short duration of efficacy and frequent administration pose challenges, leading to drug wastage and potential adverse effects. To overcome these limitations, we devised a novel approach to formulate DEX-Gel by incorporating dexamethasone (DEX) into a blend of Pluronic F127, stearic acid (SA), and polyethylene glycol 400 (PEG400) to achieve sustained-release treatment for AR.
RESULTS: Following endoscopic injection into the nasal mucosa of AR rats, DEX-Gel exhibited sustained release over a 14-day period. In vivo trials employing various assays, such as flow cytometry (FC), demonstrated that DEX-Gel not only effectively managed allergic symptoms but also significantly downregulated helper T-cells (TH) 2 and TH2-type inflammatory cytokines (e.g., interleukins 4, 5, and 13). Additionally, the TH1/TH2 cell ratio was increased.
CONCLUSION: This innovative long-acting anti-inflammatory sustained-release therapy addresses the TH1/TH2 immune imbalance, offering a promising and valuable approach for the treatment of AR and other inflammatory nasal diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Journal of nanobiotechnology - 22(2024), 1 vom: 06. Feb., Seite 51 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dai, Li [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 08.02.2024 Date Revised 10.02.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12951-024-02306-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368107507 |
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| 520 | |a © 2024. The Author(s). | ||
| 520 | |a BACKGROUND: Allergic rhinitis (AR) is a prevalent immune-related allergic disease, and corticosteroid nasal sprays serve as the primary treatment for this patient population. However, their short duration of efficacy and frequent administration pose challenges, leading to drug wastage and potential adverse effects. To overcome these limitations, we devised a novel approach to formulate DEX-Gel by incorporating dexamethasone (DEX) into a blend of Pluronic F127, stearic acid (SA), and polyethylene glycol 400 (PEG400) to achieve sustained-release treatment for AR | ||
| 520 | |a RESULTS: Following endoscopic injection into the nasal mucosa of AR rats, DEX-Gel exhibited sustained release over a 14-day period. In vivo trials employing various assays, such as flow cytometry (FC), demonstrated that DEX-Gel not only effectively managed allergic symptoms but also significantly downregulated helper T-cells (TH) 2 and TH2-type inflammatory cytokines (e.g., interleukins 4, 5, and 13). Additionally, the TH1/TH2 cell ratio was increased | ||
| 520 | |a CONCLUSION: This innovative long-acting anti-inflammatory sustained-release therapy addresses the TH1/TH2 immune imbalance, offering a promising and valuable approach for the treatment of AR and other inflammatory nasal diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Allergic rhinitis | |
| 650 | 4 | |a Injectable gel | |
| 650 | 4 | |a Minimally invasive treatment | |
| 650 | 4 | |a Sustained-release anti-inflammatory | |
| 650 | 4 | |a TH1/TH2 immune balance | |
| 650 | 7 | |a Delayed-Action Preparations |2 NLM | |
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| 700 | 1 | |a Lin, Jiangtao |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Yongquan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yuanyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Zhuowei |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Silin |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Yiming |e verfasserin |4 aut | |
| 700 | 1 | |a Duan, Yourong |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jiping |e verfasserin |4 aut | |
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