Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma
Tezepelumab and Mucus Plugs in Patients with AsthmaMucus plugs in airways of asthma patients are associated with airway obstruction and the activity of inflammatory cytokines. This article reports prespecified and post hoc analyses of the effect of tezepelumab treatment on mucus plugs identified by computed tomography imaging in patients with moderate-to-severe asthma. At baseline, mucus plug scores correlated positively with levels of inflammatory biomarkers and negatively with lung function measures. Patients treated with tezepelumab had resolution of more mucus plugs than patients taking placebo.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2 |
|---|---|
| Enthalten in: |
NEJM evidence - 2(2023), 10 vom: 01. Okt., Seite EVIDoa2300135 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Nordenmark, Lars H [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antibodies, Monoclonal, Humanized |
|---|
| Anmerkungen: |
Date Completed 10.02.2024 Date Revised 10.02.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1056/EVIDoa2300135 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368095770 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368095770 | ||
| 003 | DE-627 | ||
| 005 | 20240211232016.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240207s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1056/EVIDoa2300135 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1288.xml |
| 035 | |a (DE-627)NLM368095770 | ||
| 035 | |a (NLM)38320181 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Nordenmark, Lars H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 10.02.2024 | ||
| 500 | |a Date Revised 10.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Tezepelumab and Mucus Plugs in Patients with AsthmaMucus plugs in airways of asthma patients are associated with airway obstruction and the activity of inflammatory cytokines. This article reports prespecified and post hoc analyses of the effect of tezepelumab treatment on mucus plugs identified by computed tomography imaging in patients with moderate-to-severe asthma. At baseline, mucus plug scores correlated positively with levels of inflammatory biomarkers and negatively with lung function measures. Patients treated with tezepelumab had resolution of more mucus plugs than patients taking placebo | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antibodies, Monoclonal, Humanized |2 NLM | |
| 650 | 7 | |a tezepelumab |2 NLM | |
| 650 | 7 | |a RJ1IW3B4QX |2 NLM | |
| 700 | 1 | |a Hellqvist, Åsa |e verfasserin |4 aut | |
| 700 | 1 | |a Emson, Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Diver, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Porsbjerg, Celeste |e verfasserin |4 aut | |
| 700 | 1 | |a Griffiths, Janet M |e verfasserin |4 aut | |
| 700 | 1 | |a Newell, John D |e verfasserin |4 aut | |
| 700 | 1 | |a Peterson, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Pawlikowska, Beata |e verfasserin |4 aut | |
| 700 | 1 | |a Parnes, Jane R |e verfasserin |4 aut | |
| 700 | 1 | |a Megally, Ayman |e verfasserin |4 aut | |
| 700 | 1 | |a Colice, Gene |e verfasserin |4 aut | |
| 700 | 1 | |a Brightling, Christopher E |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t NEJM evidence |d 2022 |g 2(2023), 10 vom: 01. Okt., Seite EVIDoa2300135 |w (DE-627)NLM339641495 |x 2766-5526 |7 nnns |
| 773 | 1 | 8 | |g volume:2 |g year:2023 |g number:10 |g day:01 |g month:10 |g pages:EVIDoa2300135 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1056/EVIDoa2300135 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 2 |j 2023 |e 10 |b 01 |c 10 |h EVIDoa2300135 | ||