Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma
© 2024. The Author(s)..
Ginger has been associated with a decreased incidence of colorectal cancer (CRC) through reduction in inflammatory pathways and inhibition of tumor growth. Recent pre-clinical models have implicated changes in the gut microbiome as a possible mediator of the ginger effect on CRC. We hypothesized that, in adults previously diagnosed with a colorectal adenoma, ginger supplementation would alter the fecal microbiome in the direction consistent with its CRC-inhibitory effect. Sixty-eight adults were randomized to take either ginger or placebo daily for 6 weeks, with a 6-week washout and longitudinal stool collection throughout. We performed 16S rRNA sequencing and evaluated changes in overall microbial diversity and the relative abundances of pre-specified CRC-associated taxa using mixed-effects logistic regression. Ginger supplementation showed no significant effect on microbial community structure through alpha or beta diversity. Of 10 pre-specified CRC-associated taxa, there were significant decreases in the relative abundances of the genera Akkermansia (p < 0.001), Bacteroides (p = 0.018), and Ruminococcus (p = 0.013) after 6-week treatment with ginger compared to placebo. Ginger supplementation led to decreased abundances of Akkermansia and Bacteroides, which suggests that ginger may have an inhibitory effect on CRC-associated taxa. Overall, ginger supplementation appears to have a limited effect on gut microbiome in patients with colorectal adenomas.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
---|---|
Enthalten in: |
Scientific reports - 14(2024), 1 vom: 05. Feb., Seite 2988 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Prakash, Ajay [VerfasserIn] |
---|
Links: |
---|
Themen: |
Journal Article |
---|
Anmerkungen: |
Date Completed 07.02.2024 Date Revised 10.02.2024 published: Electronic Citation Status MEDLINE |
---|
doi: |
10.1038/s41598-024-52658-4 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM368060667 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM368060667 | ||
003 | DE-627 | ||
005 | 20240210233227.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240206s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1038/s41598-024-52658-4 |2 doi | |
028 | 5 | 2 | |a pubmed24n1287.xml |
035 | |a (DE-627)NLM368060667 | ||
035 | |a (NLM)38316805 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Prakash, Ajay |e verfasserin |4 aut | |
245 | 1 | 0 | |a Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 07.02.2024 | ||
500 | |a Date Revised 10.02.2024 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2024. The Author(s). | ||
520 | |a Ginger has been associated with a decreased incidence of colorectal cancer (CRC) through reduction in inflammatory pathways and inhibition of tumor growth. Recent pre-clinical models have implicated changes in the gut microbiome as a possible mediator of the ginger effect on CRC. We hypothesized that, in adults previously diagnosed with a colorectal adenoma, ginger supplementation would alter the fecal microbiome in the direction consistent with its CRC-inhibitory effect. Sixty-eight adults were randomized to take either ginger or placebo daily for 6 weeks, with a 6-week washout and longitudinal stool collection throughout. We performed 16S rRNA sequencing and evaluated changes in overall microbial diversity and the relative abundances of pre-specified CRC-associated taxa using mixed-effects logistic regression. Ginger supplementation showed no significant effect on microbial community structure through alpha or beta diversity. Of 10 pre-specified CRC-associated taxa, there were significant decreases in the relative abundances of the genera Akkermansia (p < 0.001), Bacteroides (p = 0.018), and Ruminococcus (p = 0.013) after 6-week treatment with ginger compared to placebo. Ginger supplementation led to decreased abundances of Akkermansia and Bacteroides, which suggests that ginger may have an inhibitory effect on CRC-associated taxa. Overall, ginger supplementation appears to have a limited effect on gut microbiome in patients with colorectal adenomas | ||
650 | 4 | |a Randomized Controlled Trial | |
650 | 4 | |a Journal Article | |
650 | 7 | |a RNA, Ribosomal, 16S |2 NLM | |
700 | 1 | |a Rubin, Nathan |e verfasserin |4 aut | |
700 | 1 | |a Staley, Christopher |e verfasserin |4 aut | |
700 | 1 | |a Onyeaghala, Guillaume |e verfasserin |4 aut | |
700 | 1 | |a Wen, Ya-Feng |e verfasserin |4 aut | |
700 | 1 | |a Shaukat, Aasma |e verfasserin |4 aut | |
700 | 1 | |a Milne, Ginger |e verfasserin |4 aut | |
700 | 1 | |a Straka, Robert J |e verfasserin |4 aut | |
700 | 1 | |a Church, Timothy R |e verfasserin |4 aut | |
700 | 1 | |a Prizment, Anna |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Scientific reports |d 2011 |g 14(2024), 1 vom: 05. Feb., Seite 2988 |w (DE-627)NLM215703936 |x 2045-2322 |7 nnns |
773 | 1 | 8 | |g volume:14 |g year:2024 |g number:1 |g day:05 |g month:02 |g pages:2988 |
856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41598-024-52658-4 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 14 |j 2024 |e 1 |b 05 |c 02 |h 2988 |