Investigation of gadolinium doped manganese nano spinel ferrites via magnetic hypothermia therapy effect towards MCF-7 breast cancer
© 2024 The Authors..
Magnetic spinel ferrite nanoparticles (MSF-NPs) are potential candidates for biomedical applications, especially in cancer diagnosis and therapy due to their excellent physiochemical and magnetic properties. In the current study, MSF-NPs were fabricated by sol-gel auto combustion method. The crystal structure and surface morphology were confirmed by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The magnetic properties were studied by VSM (vibrating sample magnetometer). As increasing Gd3+ concentration, the saturation magnetization values decreased from (17.8-2.3) emu/g, while the coercivity decreased from (499-133) Oe at room temperature. Finally, the fabricated MSF-NPs were tested against anticancer activity by MTT assay. The IC50 = 21.27 μg/mL value was observed, showing the strong antiproliferative activity of these nanoparticles. These results suggested that the obtained MSF-NPs would be useful for remote-controlled hyperthermia therapy for cancer treatment and MRI application due to their excellent magnetic properties. These distinct properties make MSF-NPs most suitable for cancer treatment and bright Contrast Agents (T1-MRI).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Heliyon - 10(2024), 3 vom: 15. Feb., Seite e24792 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tahir, M [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Revised 06.02.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.heliyon.2024.e24792 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM368035255 |
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| 520 | |a © 2024 The Authors. | ||
| 520 | |a Magnetic spinel ferrite nanoparticles (MSF-NPs) are potential candidates for biomedical applications, especially in cancer diagnosis and therapy due to their excellent physiochemical and magnetic properties. In the current study, MSF-NPs were fabricated by sol-gel auto combustion method. The crystal structure and surface morphology were confirmed by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The magnetic properties were studied by VSM (vibrating sample magnetometer). As increasing Gd3+ concentration, the saturation magnetization values decreased from (17.8-2.3) emu/g, while the coercivity decreased from (499-133) Oe at room temperature. Finally, the fabricated MSF-NPs were tested against anticancer activity by MTT assay. The IC50 = 21.27 μg/mL value was observed, showing the strong antiproliferative activity of these nanoparticles. These results suggested that the obtained MSF-NPs would be useful for remote-controlled hyperthermia therapy for cancer treatment and MRI application due to their excellent magnetic properties. These distinct properties make MSF-NPs most suitable for cancer treatment and bright Contrast Agents (T1-MRI) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a Magnetic hyperthermia therapy | |
| 650 | 4 | |a Magnetic spinal ferrites | |
| 650 | 4 | |a VSM and MCF-7 | |
| 700 | 1 | |a Fakhar-E-Alam, M |e verfasserin |4 aut | |
| 700 | 1 | |a Asif, Muhammad |e verfasserin |4 aut | |
| 700 | 1 | |a Iqbal, M Javaid |e verfasserin |4 aut | |
| 700 | 1 | |a Abbas, Aoun |e verfasserin |4 aut | |
| 700 | 1 | |a Hassan, Mudassir |e verfasserin |4 aut | |
| 700 | 1 | |a Rehman, Javed |e verfasserin |4 aut | |
| 700 | 1 | |a Bhatti, Qaisar Abbas |e verfasserin |4 aut | |
| 700 | 1 | |a Mustafa, Ghulam |e verfasserin |4 aut | |
| 700 | 1 | |a Alothman, Asma A |e verfasserin |4 aut | |
| 700 | 1 | |a Mohammad, Saikh |e verfasserin |4 aut | |
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