Leukocyte immunoglobulin-like receptor B2 : A promising biomarker for colorectal cancer
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved..
According to the latest global cancer statistics, colorectal cancer (CRC) has emerged as the third most prevalent malignant tumor across the globe. In recent decades, the medical field has implemented several levels of CRC screening tests, encompassing fecal tests, endoscopic examinations, radiological examinations and blood tests. Previous studies have shown that leukocyte immunoglobulin-like receptor B2 (LILRB2) is involved in inhibiting immune cell function, immune evasion, and promoting tumor progression in acute myeloid leukemia and non-small cell lung cancer. However, its interaction with CRC has not been reported yet. Recently, a study published in the World Journal of Gastroenterology revealed that LILRB2 and its ligand, angiopoietin-like protein 2, are markedly overexpressed in CRC. This overexpression is closely linked to tumor progression and is indicative of a poor prognosis. The study highlights the potential of utilizing the concentration of LILRB2 in serum as a promising biomarker for tumors. However, there is still room for discussion regarding the data processing and analysis in this research.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
World journal of gastroenterology - 30(2024), 4 vom: 28. Jan., Seite 421-423 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Wen-Zhuo [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 06.02.2024 Date Revised 06.02.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.3748/wjg.v30.i4.421 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368024385 |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. | ||
| 520 | |a According to the latest global cancer statistics, colorectal cancer (CRC) has emerged as the third most prevalent malignant tumor across the globe. In recent decades, the medical field has implemented several levels of CRC screening tests, encompassing fecal tests, endoscopic examinations, radiological examinations and blood tests. Previous studies have shown that leukocyte immunoglobulin-like receptor B2 (LILRB2) is involved in inhibiting immune cell function, immune evasion, and promoting tumor progression in acute myeloid leukemia and non-small cell lung cancer. However, its interaction with CRC has not been reported yet. Recently, a study published in the World Journal of Gastroenterology revealed that LILRB2 and its ligand, angiopoietin-like protein 2, are markedly overexpressed in CRC. This overexpression is closely linked to tumor progression and is indicative of a poor prognosis. The study highlights the potential of utilizing the concentration of LILRB2 in serum as a promising biomarker for tumors. However, there is still room for discussion regarding the data processing and analysis in this research | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Angiopoietin-like protein 2 | |
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a Leukocyte immunoglobulin-like receptor B2 | |
| 650 | 4 | |a Noninvasive screening biomarker | |
| 650 | 4 | |a Therapeutic target | |
| 650 | 7 | |a Membrane Glycoproteins |2 NLM | |
| 650 | 7 | |a Biomarkers, Tumor |2 NLM | |
| 650 | 7 | |a LILRB2 protein, human |2 NLM | |
| 650 | 7 | |a Receptors, Immunologic |2 NLM | |
| 700 | 1 | |a Wang, Hong-Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xiao-Zhong |e verfasserin |4 aut | |
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