Acute cerebrovascular events and inflammatory markers associated with COVID-19 : An observational study
© 2023 The Author(s)..
The novel Coronavirus disease (COVID-19) is associated with an increased risk of cerebrovascular events. About 1,228 cases of severe COVID-19 were hospitalized in the West Kazakhstan Medical University Hospital, in Aktobe, Kazakhstan, 1.22% (N=15) of whom were clinically diagnosed with acute cerebrovascular events and were included in the current study. COVID-19 was diagnosed using a nasopharyngeal polymerase chain reaction (PCR) test, blood count, inflammatory markers, and chest computerized tomography. The diagnosis of acute cerebrovascular events was based on the clinical manifestation. The participants' data were reviewed to detect the prevalence of acute cerebrovascular events and the inflammatory markers associated with COVID-19 infection. The mean age of the participants was 66.9 years (±11.07), 53% (N=8) of them were male, while 47% (N=7) were female. Moreover, 13% (N=2) presented a history of cerebrovascular events, 87% (N=13) of the participants had hypertension, 47% (N=7) had coronary heart disease, 33% (N=5) had diabetes mellitus (DM), 13% (N=2) had cardiac arrhythmia, and 13% (N=2) had chronic obstructive pulmonary disease (COPD). The C-reactive protein was high in 100% (N=15) of participants, D-dimer in 87% (N=13) of them, and both the ferritin and interleukin-6 were high in 60% (N=9) of the participants. SARS-CoV-2 causes a systemic inflammatory response, and the presence of comorbidities increases the risk of acute cerebrovascular events in COVID-19-infected individuals. The elevated inflammatory markers in severely COVID-19-infected individuals support the inflammatory "cytokine storm" response theory.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Journal of medicine and life - 16(2023), 10 vom: 01. Okt., Seite 1482-1487 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jumagaliyeva, Merey Bakytzhanovna [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.02.2024 Date Revised 14.02.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.25122/jml-2023-0283 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368023877 |
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| 100 | 1 | |a Jumagaliyeva, Merey Bakytzhanovna |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acute cerebrovascular events and inflammatory markers associated with COVID-19 |b An observational study |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 14.02.2024 | ||
| 500 | |a Date Revised 14.02.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Author(s). | ||
| 520 | |a The novel Coronavirus disease (COVID-19) is associated with an increased risk of cerebrovascular events. About 1,228 cases of severe COVID-19 were hospitalized in the West Kazakhstan Medical University Hospital, in Aktobe, Kazakhstan, 1.22% (N=15) of whom were clinically diagnosed with acute cerebrovascular events and were included in the current study. COVID-19 was diagnosed using a nasopharyngeal polymerase chain reaction (PCR) test, blood count, inflammatory markers, and chest computerized tomography. The diagnosis of acute cerebrovascular events was based on the clinical manifestation. The participants' data were reviewed to detect the prevalence of acute cerebrovascular events and the inflammatory markers associated with COVID-19 infection. The mean age of the participants was 66.9 years (±11.07), 53% (N=8) of them were male, while 47% (N=7) were female. Moreover, 13% (N=2) presented a history of cerebrovascular events, 87% (N=13) of the participants had hypertension, 47% (N=7) had coronary heart disease, 33% (N=5) had diabetes mellitus (DM), 13% (N=2) had cardiac arrhythmia, and 13% (N=2) had chronic obstructive pulmonary disease (COPD). The C-reactive protein was high in 100% (N=15) of participants, D-dimer in 87% (N=13) of them, and both the ferritin and interleukin-6 were high in 60% (N=9) of the participants. SARS-CoV-2 causes a systemic inflammatory response, and the presence of comorbidities increases the risk of acute cerebrovascular events in COVID-19-infected individuals. The elevated inflammatory markers in severely COVID-19-infected individuals support the inflammatory "cytokine storm" response theory | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ACE2: Angiotensin-converting enzyme II | |
| 650 | 4 | |a ASA: American Stroke Association | |
| 650 | 4 | |a COPD: Chronic obstructive pulmonary disease | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a COVID-19: Coronavirus disease-19 | |
| 650 | 4 | |a CRP: C-reactive protein | |
| 650 | 4 | |a CT: Computerized tomography | |
| 650 | 4 | |a CVS: Cerebrovascular stroke | |
| 650 | 4 | |a DM: Diabetes Mellitus | |
| 650 | 4 | |a ESR: Erythrocyte sedimentation rate | |
| 650 | 4 | |a GCS: Glasgow coma scale | |
| 650 | 4 | |a ICH: Intracerebral hemorrhage | |
| 650 | 4 | |a ICU: Intensive care unit | |
| 650 | 4 | |a IL-6: Interleukin-6 | |
| 650 | 4 | |a IS: Ischemic stroke | |
| 650 | 4 | |a LDH: Lactate dehydrogenase | |
| 650 | 4 | |a MRC: Medical Research Council | |
| 650 | 4 | |a MRI: Magnetic resonance imaging | |
| 650 | 4 | |a NIHSS: National Institutes of Health Stroke Scale | |
| 650 | 4 | |a PCR: Polymerase chain reaction | |
| 650 | 4 | |a WKMU: West Kazakhstan Medical University | |
| 650 | 4 | |a cerebrovascular events | |
| 650 | 4 | |a inflammatory markers | |
| 700 | 1 | |a Ayaganov, Dinmukhamed Nurniyazovich |e verfasserin |4 aut | |
| 700 | 1 | |a Abdelazim, Ibrahim Anwar |e verfasserin |4 aut | |
| 700 | 1 | |a Saparbayev, Samat Sagatovich |e verfasserin |4 aut | |
| 700 | 1 | |a Tuychibaeva, Nodira Miratalievna |e verfasserin |4 aut | |
| 700 | 1 | |a Kurmambayev, Yergen Jumashevich |e verfasserin |4 aut | |
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