Research progress on the pathogenesis of chest tightness variant asthma characterized by chest tightness
Chest tightness variant asthma (CTVA) is an atypical form of asthma with chest tightness as the sole or predominant symptom. The underlying receptors for chest tightness may be bronchial C-fibers or rapidly adapting receptors. The nerve impulses are transmitted via the vagus nerve and processed in different regions of the cerebral cortex. Chest tightness is associated with sensory perception, and CTVA patients may have a heightened ability to detect subtle changes in lung function, which may be unrelated to respiratory muscle activity, lung hyperinflation, or mechanical loading of the respiratory system. The airway inflammation, pulmonary ventilation dysfunction (especially involving small airways), and airway hyperresponsiveness may underlie the sensation of chest tightness. CTVA patients are prone to comorbid anxiety and depression, which share similar central nervous system processing pathways with dyspnea, suggesting a possible neurological basis for the development of CTVA. This article examines the recognition and mechanisms of chest tightness symptoms, and explores the pathogenesis of CTVA, focusing on its association with the airway inflammation, ventilation dysfunction, airway hyperresponsiveness, and psychosocial factors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences - (2024) vom: 03. Feb., Seite 1-8 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
以胸闷为特点的胸闷变异性哮喘发病机制研究进展 |
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| Beteiligte Personen: |
Che, Luanqing [VerfasserIn] |
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| Links: |
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| Themen: |
Airway inflammation |
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| Anmerkungen: |
Date Revised 03.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.3724/zdxbyxb-2023-0442 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367995603 |
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| 245 | 1 | 0 | |a Research progress on the pathogenesis of chest tightness variant asthma characterized by chest tightness |
| 246 | 3 | 3 | |a 以胸闷为特点的胸闷变异性哮喘发病机制研究进展 |
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| 520 | |a Chest tightness variant asthma (CTVA) is an atypical form of asthma with chest tightness as the sole or predominant symptom. The underlying receptors for chest tightness may be bronchial C-fibers or rapidly adapting receptors. The nerve impulses are transmitted via the vagus nerve and processed in different regions of the cerebral cortex. Chest tightness is associated with sensory perception, and CTVA patients may have a heightened ability to detect subtle changes in lung function, which may be unrelated to respiratory muscle activity, lung hyperinflation, or mechanical loading of the respiratory system. The airway inflammation, pulmonary ventilation dysfunction (especially involving small airways), and airway hyperresponsiveness may underlie the sensation of chest tightness. CTVA patients are prone to comorbid anxiety and depression, which share similar central nervous system processing pathways with dyspnea, suggesting a possible neurological basis for the development of CTVA. This article examines the recognition and mechanisms of chest tightness symptoms, and explores the pathogenesis of CTVA, focusing on its association with the airway inflammation, ventilation dysfunction, airway hyperresponsiveness, and psychosocial factors | ||
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| 700 | 1 | |a Shen, Huahao |e verfasserin |4 aut | |
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