A fluorogenic nitric oxide donor induced by yellow LED light for cells proliferation inhibition and imaging
Copyright © 2024 Elsevier Inc. All rights reserved..
Nitric oxide (NO), as a vital cellular signalling molecule in physiological processes, has been found to play an important role in various biological functions. In this study, we rationally designed three NO donors by tethering nitrobenzene derivatives to three fluorescent chromophores. NX-NO was found to release NO and exhibit a high fluorescence turn-on signal ratio upon exposure to LED yellow light. Additionally, it had excellent photo-stability and good inhibitory activity against cancer cell proliferation, and was successfully applied to cell imaging. Moreover, we detected the release of NO and fluorescence response in the blood of a mouse, suggesting its potential therapeutic application in living organisms.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:145 |
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| Enthalten in: |
Nitric oxide : biology and chemistry - 145(2024) vom: 01. März, Seite 1-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shen, Wei [VerfasserIn] |
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| Links: |
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| Themen: |
31C4KY9ESH |
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| Anmerkungen: |
Date Completed 22.03.2024 Date Revised 22.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.niox.2024.01.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Nitric oxide (NO), as a vital cellular signalling molecule in physiological processes, has been found to play an important role in various biological functions. In this study, we rationally designed three NO donors by tethering nitrobenzene derivatives to three fluorescent chromophores. NX-NO was found to release NO and exhibit a high fluorescence turn-on signal ratio upon exposure to LED yellow light. Additionally, it had excellent photo-stability and good inhibitory activity against cancer cell proliferation, and was successfully applied to cell imaging. Moreover, we detected the release of NO and fluorescence response in the blood of a mouse, suggesting its potential therapeutic application in living organisms | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Liu, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Jianze |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Shian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Haihua |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Qing |e verfasserin |4 aut | |
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