A new strategy for intervertebral disc regeneration : The synergistic potential of mesenchymal stem cells and their extracellular vesicles with hydrogel scaffolds
Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved..
Intervertebral disc degeneration (IDD) is a disease that severely affects spinal health and is prevalent worldwide. Mesenchymal stem cells (MSCs) and their derived extracellular vesicles (EVs) have regenerative potential and have emerged as promising therapeutic tools for treating degenerative discs. However, challenges such as the harsh microenvironment of degenerated intervertebral discs and EVs' limited stability and efficacy have hindered their clinical application. In recent years, hydrogels have attracted much attention in the field of IDD therapy because they can mimic the physiologic microenvironment of the disc and provide a potential solution by providing a suitable growth environment for MSCs and EVs. This review introduced the biological properties of MSCs and their derived EVs, summarized the research on the application of MSCs and EVs in IDD, summarized the current clinical trial studies of MSCs and EVs, and also explored the mechanism of action of MSCs and EVs in intervertebral discs. In addition, plenty of research elaborated on the mechanism of action of different classified hydrogels in tissue engineering, the synergistic effect of MSCs and EVs in promoting intervertebral disc regeneration, and their wide application in treating IDD. Finally, the challenges and problems still faced by hydrogel-loaded MSCs and EVs in the treatment of IDD are summarized, and potential solutions are proposed. This paper outlines the synergistic effects of MSCs and EVs in treating IDD in combination with hydrogels and aims to provide theoretical references for future related studies.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:172 |
|---|---|
| Enthalten in: |
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 172(2024) vom: 27. März, Seite 116238 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Zhao, Yan [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Extracellular vesicles |
|---|
| Anmerkungen: |
Date Completed 04.03.2024 Date Revised 04.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.biopha.2024.116238 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM367984482 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM367984482 | ||
| 003 | DE-627 | ||
| 005 | 20240304232418.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240204s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.biopha.2024.116238 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1316.xml |
| 035 | |a (DE-627)NLM367984482 | ||
| 035 | |a (NLM)38308965 | ||
| 035 | |a (PII)S0753-3322(24)00119-7 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Zhao, Yan |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A new strategy for intervertebral disc regeneration |b The synergistic potential of mesenchymal stem cells and their extracellular vesicles with hydrogel scaffolds |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 04.03.2024 | ||
| 500 | |a Date Revised 04.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved. | ||
| 520 | |a Intervertebral disc degeneration (IDD) is a disease that severely affects spinal health and is prevalent worldwide. Mesenchymal stem cells (MSCs) and their derived extracellular vesicles (EVs) have regenerative potential and have emerged as promising therapeutic tools for treating degenerative discs. However, challenges such as the harsh microenvironment of degenerated intervertebral discs and EVs' limited stability and efficacy have hindered their clinical application. In recent years, hydrogels have attracted much attention in the field of IDD therapy because they can mimic the physiologic microenvironment of the disc and provide a potential solution by providing a suitable growth environment for MSCs and EVs. This review introduced the biological properties of MSCs and their derived EVs, summarized the research on the application of MSCs and EVs in IDD, summarized the current clinical trial studies of MSCs and EVs, and also explored the mechanism of action of MSCs and EVs in intervertebral discs. In addition, plenty of research elaborated on the mechanism of action of different classified hydrogels in tissue engineering, the synergistic effect of MSCs and EVs in promoting intervertebral disc regeneration, and their wide application in treating IDD. Finally, the challenges and problems still faced by hydrogel-loaded MSCs and EVs in the treatment of IDD are summarized, and potential solutions are proposed. This paper outlines the synergistic effects of MSCs and EVs in treating IDD in combination with hydrogels and aims to provide theoretical references for future related studies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Extracellular vesicles | |
| 650 | 4 | |a Hydrogel | |
| 650 | 4 | |a Intervertebral disc regeneration | |
| 650 | 4 | |a Mesenchymal stem cells | |
| 650 | 7 | |a Hydrogels |2 NLM | |
| 700 | 1 | |a Dong, Huaize |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Qiuqiu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yanyang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Zongyue |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Jiyue |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Qiming |e verfasserin |4 aut | |
| 700 | 1 | |a Weng, Zijing |e verfasserin |4 aut | |
| 700 | 1 | |a Yi, Jiangbi |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Shuai |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Youhong |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Wenbo |e verfasserin |4 aut | |
| 700 | 1 | |a Xin, Zhijun |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie |d 1984 |g 172(2024) vom: 27. März, Seite 116238 |w (DE-627)NLM012645591 |x 1950-6007 |7 nnns |
| 773 | 1 | 8 | |g volume:172 |g year:2024 |g day:27 |g month:03 |g pages:116238 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.biopha.2024.116238 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 172 |j 2024 |b 27 |c 03 |h 116238 | ||