pH regulators and their inhibitors in tumor microenvironment
Copyright © 2024 Elsevier Masson SAS. All rights reserved..
As an important characteristic of tumor, acidic tumor microenvironment (TME) is closely related to immune escape, invasion, migration and drug resistance of tumor. The acidity of the TME mainly comes from the acidic products produced by the high level of tumor metabolism, such as lactic acid and carbon dioxide. pH regulators such as monocarboxylate transporters (MCTs), carbonic anhydrase IX (CA IX), and Na+/H+ exchange 1 (NHE1) expel protons directly or indirectly from the tumor to maintain the pH balance of tumor cells and create an acidic TME. We review the functions of several pH regulators involved in the construction of acidic TME, the structure and structure-activity relationship of pH regulator inhibitors, and provide strategies for the development of small-molecule antitumor inhibitors based on these targets.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:267 |
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| Enthalten in: |
European journal of medicinal chemistry - 267(2024) vom: 05. Feb., Seite 116170 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liao, Senyi [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 26.02.2024 Date Revised 26.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejmech.2024.116170 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a As an important characteristic of tumor, acidic tumor microenvironment (TME) is closely related to immune escape, invasion, migration and drug resistance of tumor. The acidity of the TME mainly comes from the acidic products produced by the high level of tumor metabolism, such as lactic acid and carbon dioxide. pH regulators such as monocarboxylate transporters (MCTs), carbonic anhydrase IX (CA IX), and Na+/H+ exchange 1 (NHE1) expel protons directly or indirectly from the tumor to maintain the pH balance of tumor cells and create an acidic TME. We review the functions of several pH regulators involved in the construction of acidic TME, the structure and structure-activity relationship of pH regulator inhibitors, and provide strategies for the development of small-molecule antitumor inhibitors based on these targets | ||
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| 700 | 1 | |a Xie, Zhizhong |e verfasserin |4 aut | |
| 700 | 1 | |a Lei, Xiaoyong |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xiaoyan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Sheng |e verfasserin |4 aut | |
| 700 | 1 | |a Deng, Xiangping |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhe |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Guotao |e verfasserin |4 aut | |
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