Histone methylation readers MRG1/2 interact with PIF4 to promote thermomorphogenesis in Arabidopsis
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved..
Warm ambient conditions induce thermomorphogenesis and affect plant growth and development. However, the chromatin regulatory mechanisms involved in thermomorphogenesis remain largely obscure. In this study, we show that the histone methylation readers MORF-related gene 1 and 2 (MRG1/2) are required to promote hypocotyl elongation in response to warm ambient conditions. A transcriptome sequencing analysis indicates that MRG1/2 and phytochrome interacting factor 4 (PIF4) coactivate a number of thermoresponsive genes, including YUCCA8, which encodes a rate-limiting enzyme in the auxin biosynthesis pathway. Additionally, MRG2 physically interacts with PIF4 to bind to thermoresponsive genes and enhances the H4K5 acetylation of the chromatin of target genes in a PIF4-dependent manner. Furthermore, MRG2 competes with phyB for binding to PIF4 and stabilizes PIF4 in planta. Our study indicates that MRG1/2 activate thermoresponsive genes by inducing histone acetylation and stabilizing PIF4 in Arabidopsis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Cell reports - 43(2024), 2 vom: 27. Feb., Seite 113726 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhou, Nana [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 04.03.2024 Date Revised 04.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.celrep.2024.113726 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Warm ambient conditions induce thermomorphogenesis and affect plant growth and development. However, the chromatin regulatory mechanisms involved in thermomorphogenesis remain largely obscure. In this study, we show that the histone methylation readers MORF-related gene 1 and 2 (MRG1/2) are required to promote hypocotyl elongation in response to warm ambient conditions. A transcriptome sequencing analysis indicates that MRG1/2 and phytochrome interacting factor 4 (PIF4) coactivate a number of thermoresponsive genes, including YUCCA8, which encodes a rate-limiting enzyme in the auxin biosynthesis pathway. Additionally, MRG2 physically interacts with PIF4 to bind to thermoresponsive genes and enhances the H4K5 acetylation of the chromatin of target genes in a PIF4-dependent manner. Furthermore, MRG2 competes with phyB for binding to PIF4 and stabilizes PIF4 in planta. Our study indicates that MRG1/2 activate thermoresponsive genes by inducing histone acetylation and stabilizing PIF4 in Arabidopsis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Arabidopsis | |
| 650 | 4 | |a CP: Molecular biology | |
| 650 | 4 | |a CP: Plants | |
| 650 | 4 | |a PIF4 | |
| 650 | 4 | |a histone acetylation | |
| 650 | 4 | |a histone methylation reader | |
| 650 | 4 | |a thermomorphogenesis | |
| 650 | 7 | |a Histones |2 NLM | |
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| 650 | 7 | |a Phytochrome |2 NLM | |
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| 650 | 7 | |a PIF4 protein, Arabidopsis |2 NLM | |
| 650 | 7 | |a Arabidopsis Proteins |2 NLM | |
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| 650 | 7 | |a Chromosomal Proteins, Non-Histone |2 NLM | |
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| 700 | 1 | |a Li, Chengzhang |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Wenhao |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Ning |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jiachen |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Baihui |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Jiabing |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Wen-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Bing |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Aiwu |e verfasserin |4 aut | |
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