Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes
Three nor-sesquiterpenes, phellinharts A-C (1-3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1-3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogenic pathways involving demethylation, ring cleavage, and rearrangement were proposed. Compounds 1-3 displayed potent anti-hypertrophic activities with low cytotoxicity (CC50 > 50 μM) in rat cardiomyocytes, underscoring their therapeutic potential.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:87 |
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| Enthalten in: |
Journal of natural products - 87(2024), 2 vom: 23. Feb., Seite 297-303 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fu, Quan [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 26.02.2024 Date Revised 11.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acs.jnatprod.3c00985 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM367981297 |
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| 520 | |a Three nor-sesquiterpenes, phellinharts A-C (1-3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1-3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogenic pathways involving demethylation, ring cleavage, and rearrangement were proposed. Compounds 1-3 displayed potent anti-hypertrophic activities with low cytotoxicity (CC50 > 50 μM) in rat cardiomyocytes, underscoring their therapeutic potential | ||
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| 700 | 1 | |a Zhang, Jing-Jing |e verfasserin |4 aut | |
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| 700 | 1 | |a Zhang, Hong-Ye |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Wei-Lie |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Chang-Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiao-Li |e verfasserin |4 aut | |
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