Advances in computational quantitative nephropathology
© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature..
BACKGROUND: Semiquantitative histological scoring systems are frequently used in nephropathology. In computational nephropathology, the focus is on generating quantitative data from histology (so-called pathomics). Several recent studies have collected such data using next-generation morphometry (NGM) based on segmentations by artificial neural networks and investigated their usability for various clinical or diagnostic purposes.
AIM: To present an overview of the current state of studies regarding renal pathomics and to identify current challenges and potential solutions.
MATERIALS AND METHODS: Due to the literature restriction (maximum of 30 references), studies were selected based on a database search that processed as much data as possible, used innovative methodologies, and/or were ideally multicentric in design.
RESULTS AND DISCUSSION: Pathomics studies in the kidney have impressively demonstrated that morphometric data are useful clinically (for example, for prognosis assessment) and translationally. Further development of NGM requires overcoming some challenges, including better standardization and generation of prospective evidence.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Pathologie (Heidelberg, Germany) - 45(2024), 2 vom: 02. Feb., Seite 140-145 |
| Sprache: |
Deutsch |
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| Weiterer Titel: |
Fortschritte in der computergestützten quantitativen Nephropathologie |
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| Beteiligte Personen: |
Bülow, Roman D [VerfasserIn] |
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| Links: |
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| Themen: |
English Abstract |
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| Anmerkungen: |
Date Completed 29.02.2024 Date Revised 29.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00292-024-01300-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. | ||
| 520 | |a BACKGROUND: Semiquantitative histological scoring systems are frequently used in nephropathology. In computational nephropathology, the focus is on generating quantitative data from histology (so-called pathomics). Several recent studies have collected such data using next-generation morphometry (NGM) based on segmentations by artificial neural networks and investigated their usability for various clinical or diagnostic purposes | ||
| 520 | |a AIM: To present an overview of the current state of studies regarding renal pathomics and to identify current challenges and potential solutions | ||
| 520 | |a MATERIALS AND METHODS: Due to the literature restriction (maximum of 30 references), studies were selected based on a database search that processed as much data as possible, used innovative methodologies, and/or were ideally multicentric in design | ||
| 520 | |a RESULTS AND DISCUSSION: Pathomics studies in the kidney have impressively demonstrated that morphometric data are useful clinically (for example, for prognosis assessment) and translationally. Further development of NGM requires overcoming some challenges, including better standardization and generation of prospective evidence | ||
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| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Prospective studies | |
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| 700 | 1 | |a Boor, Peter |e verfasserin |4 aut | |
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