Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved..
In this study, the phytochemical profile of fifty olive leaves (OL) extracts from Spain, Italy, Greece, Portugal, and Morocco was characterized and their anti-cholinergic, anti-inflammatory, and antioxidant activities were evaluated. Luteolin-7-O-glucoside, isoharmnentin, and apigenin were involved in the acetylcholinesterase (AChE) inhibitory activity, while oleuropein and hydroxytyrosol showed noteworthy potential. Secoiridoids contributed to the cyclooxygenase-2 inhibitory activity and antioxidant capacity. Compounds such as oleuropein, ligstroside and luteolin-7-O-glucoside, may exert an important role in the ferric reducing antioxidant capacity. It should be also highlighted the role of hydroxytyrosol, hydroxycoumarins, and verbascoside concerning the antioxidant activity. This research provides valuable insights and confirms that specific compounds within OL extracts contribute to distinct anti-cholinergic, anti-inflammatory, and anti-oxidative effects.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:444 |
|---|---|
| Enthalten in: |
Food chemistry - 444(2024) vom: 30. März, Seite 138516 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Romero-Márquez, Jose M [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 11.03.2024 Date Revised 11.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.foodchem.2024.138516 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM367961547 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM367961547 | ||
| 003 | DE-627 | ||
| 005 | 20240311232217.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240203s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.foodchem.2024.138516 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1323.xml |
| 035 | |a (DE-627)NLM367961547 | ||
| 035 | |a (NLM)38306771 | ||
| 035 | |a (PII)S0308-8146(24)00164-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Romero-Márquez, Jose M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.03.2024 | ||
| 500 | |a Date Revised 11.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a In this study, the phytochemical profile of fifty olive leaves (OL) extracts from Spain, Italy, Greece, Portugal, and Morocco was characterized and their anti-cholinergic, anti-inflammatory, and antioxidant activities were evaluated. Luteolin-7-O-glucoside, isoharmnentin, and apigenin were involved in the acetylcholinesterase (AChE) inhibitory activity, while oleuropein and hydroxytyrosol showed noteworthy potential. Secoiridoids contributed to the cyclooxygenase-2 inhibitory activity and antioxidant capacity. Compounds such as oleuropein, ligstroside and luteolin-7-O-glucoside, may exert an important role in the ferric reducing antioxidant capacity. It should be also highlighted the role of hydroxytyrosol, hydroxycoumarins, and verbascoside concerning the antioxidant activity. This research provides valuable insights and confirms that specific compounds within OL extracts contribute to distinct anti-cholinergic, anti-inflammatory, and anti-oxidative effects | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a AChE | |
| 650 | 4 | |a COX | |
| 650 | 4 | |a Cholinergic | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Iron | |
| 650 | 4 | |a Leaves | |
| 650 | 4 | |a Olive | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a oleuropein |2 NLM | |
| 650 | 7 | |a 2O4553545L |2 NLM | |
| 650 | 7 | |a Acetylcholinesterase |2 NLM | |
| 650 | 7 | |a EC 3.1.1.7 |2 NLM | |
| 650 | 7 | |a Cyclooxygenase 2 |2 NLM | |
| 650 | 7 | |a EC 1.14.99.1 |2 NLM | |
| 650 | 7 | |a 3,4-dihydroxyphenylethanol |2 NLM | |
| 650 | 7 | |a 10597-60-1 |2 NLM | |
| 650 | 7 | |a Plant Extracts |2 NLM | |
| 650 | 7 | |a Iridoids |2 NLM | |
| 650 | 7 | |a Phytochemicals |2 NLM | |
| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
| 650 | 7 | |a Cholinergic Antagonists |2 NLM | |
| 650 | 7 | |a Phenylethyl Alcohol |2 NLM | |
| 650 | 7 | |a ML9LGA7468 |2 NLM | |
| 650 | 7 | |a Iridoid Glucosides |2 NLM | |
| 700 | 1 | |a Navarro-Hortal, María D |e verfasserin |4 aut | |
| 700 | 1 | |a Forbes-Hernández, Tamara Y |e verfasserin |4 aut | |
| 700 | 1 | |a Varela-López, Alfonso |e verfasserin |4 aut | |
| 700 | 1 | |a Puentes, Juan G |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-González, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Sumalla-Cano, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Battino, Maurizio |e verfasserin |4 aut | |
| 700 | 1 | |a García-Ruiz, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez, Sebastián |e verfasserin |4 aut | |
| 700 | 1 | |a Quiles, José L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Food chemistry |d 1995 |g 444(2024) vom: 30. März, Seite 138516 |w (DE-627)NLM076785823 |x 1873-7072 |7 nnns |
| 773 | 1 | 8 | |g volume:444 |g year:2024 |g day:30 |g month:03 |g pages:138516 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.foodchem.2024.138516 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 444 |j 2024 |b 30 |c 03 |h 138516 | ||