A Case of TMB-High Recurrent Peritoneal Seeding in Hilar Cholangiocarcinoma Treated with Pembrolizumab Therapy
Tumor mutation burden(TMB)-High is known to potentially elicit a favorable response to immune checkpoint inhibitors. In this report, we present a case of recurrent hilar cholangiocarcinoma with TMB-High, in which we performed comprehensive treatment including immune checkpoint inhibitor pembrolizumab. The patient was a 58-year-old male diagnosed with hilar cholangiocarcinoma who underwent extended right hepatectomy, caudate lobe resection, bile duct excision, and bile duct reconstruction. Postoperatively, peritoneal seeding recurrence and liver metastasis were observed, indicating TMB-High. Therefore, pembrolizumab therapy was administered. The tumor marker CA19-9 significantly decreased, and the peritoneal seeding and liver metastatic lesions disappeared on imaging. In this case, we experienced the use of pembrolizumab monotherapy for TMB-High recurrent bile duct cancer with early postoperative peritoneal seeding recurrence. Further accumulation of cases is needed, but pembrolizumab monotherapy holds promise as a treatment option for TMB-High bile duct cancer at the hepatic hilum.
Medienart: |
Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:50 |
---|---|
Enthalten in: |
Gan to kagaku ryoho. Cancer & chemotherapy - 50(2023), 13 vom: 02. Dez., Seite 1875-1877 |
Sprache: |
Japanisch |
---|
Beteiligte Personen: |
Shinke, Go [VerfasserIn] |
---|
Themen: |
Antibodies, Monoclonal, Humanized |
---|
Anmerkungen: |
Date Completed 05.02.2024 Date Revised 05.02.2024 published: Print Citation Status MEDLINE |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
NLM367925990 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM367925990 | ||
003 | DE-627 | ||
005 | 20240205232121.0 | ||
007 | tu | ||
008 | 240202s2023 xx ||||| 00| ||jpn c | ||
028 | 5 | 2 | |a pubmed24n1281.xml |
035 | |a (DE-627)NLM367925990 | ||
035 | |a (NLM)38303237 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a jpn | ||
100 | 1 | |a Shinke, Go |e verfasserin |4 aut | |
245 | 1 | 2 | |a A Case of TMB-High Recurrent Peritoneal Seeding in Hilar Cholangiocarcinoma Treated with Pembrolizumab Therapy |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a Date Completed 05.02.2024 | ||
500 | |a Date Revised 05.02.2024 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Tumor mutation burden(TMB)-High is known to potentially elicit a favorable response to immune checkpoint inhibitors. In this report, we present a case of recurrent hilar cholangiocarcinoma with TMB-High, in which we performed comprehensive treatment including immune checkpoint inhibitor pembrolizumab. The patient was a 58-year-old male diagnosed with hilar cholangiocarcinoma who underwent extended right hepatectomy, caudate lobe resection, bile duct excision, and bile duct reconstruction. Postoperatively, peritoneal seeding recurrence and liver metastasis were observed, indicating TMB-High. Therefore, pembrolizumab therapy was administered. The tumor marker CA19-9 significantly decreased, and the peritoneal seeding and liver metastatic lesions disappeared on imaging. In this case, we experienced the use of pembrolizumab monotherapy for TMB-High recurrent bile duct cancer with early postoperative peritoneal seeding recurrence. Further accumulation of cases is needed, but pembrolizumab monotherapy holds promise as a treatment option for TMB-High bile duct cancer at the hepatic hilum | ||
650 | 4 | |a Case Reports | |
650 | 4 | |a English Abstract | |
650 | 4 | |a Journal Article | |
650 | 7 | |a pembrolizumab |2 NLM | |
650 | 7 | |a DPT0O3T46P |2 NLM | |
650 | 7 | |a Antibodies, Monoclonal, Humanized |2 NLM | |
700 | 1 | |a Takeda, Yutaka |e verfasserin |4 aut | |
700 | 1 | |a Ohmura, Yoshiaki |e verfasserin |4 aut | |
700 | 1 | |a Kinoshita, Mitsuru |e verfasserin |4 aut | |
700 | 1 | |a Katsura, Yoshiteru |e verfasserin |4 aut | |
700 | 1 | |a Aoyama, Shu |e verfasserin |4 aut | |
700 | 1 | |a Kihara, Yukari |e verfasserin |4 aut | |
700 | 1 | |a Yanagisawa, Kiminori |e verfasserin |4 aut | |
700 | 1 | |a Katsuyama, Shinsuke |e verfasserin |4 aut | |
700 | 1 | |a Ikeshima, Ryo |e verfasserin |4 aut | |
700 | 1 | |a Hiraki, Masayuki |e verfasserin |4 aut | |
700 | 1 | |a Sugimura, Keijiro |e verfasserin |4 aut | |
700 | 1 | |a Masuzawa, Toru |e verfasserin |4 aut | |
700 | 1 | |a Hata, Taishi |e verfasserin |4 aut | |
700 | 1 | |a Murata, Kohei |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Gan to kagaku ryoho. Cancer & chemotherapy |d 1993 |g 50(2023), 13 vom: 02. Dez., Seite 1875-1877 |w (DE-627)NLM012601861 |x 0385-0684 |7 nnns |
773 | 1 | 8 | |g volume:50 |g year:2023 |g number:13 |g day:02 |g month:12 |g pages:1875-1877 |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 50 |j 2023 |e 13 |b 02 |c 12 |h 1875-1877 |