Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058
© 2024. The Author(s), under exclusive licence to the Japan Antibiotics Research Association..
Two new pramanicin analogs, named virgaricins C (1) and D (2), were discovered by physicochemical screening from a static cultured material of Apiospora sp. FKI-8058. Their structures were elucidated by MS and NMR analyses and chemical derivatization. Compounds 1 and 2 showed moderate antimalarial activity and cytotoxicity.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:77 |
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| Enthalten in: |
The Journal of antibiotics - 77(2024), 4 vom: 28. Apr., Seite 206-213 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kimura, So-Ichiro [VerfasserIn] |
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| Links: |
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| Themen: |
Antimalarials |
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| Anmerkungen: |
Date Completed 28.03.2024 Date Revised 16.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41429-023-00699-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367921081 |
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| 520 | |a Two new pramanicin analogs, named virgaricins C (1) and D (2), were discovered by physicochemical screening from a static cultured material of Apiospora sp. FKI-8058. Their structures were elucidated by MS and NMR analyses and chemical derivatization. Compounds 1 and 2 showed moderate antimalarial activity and cytotoxicity | ||
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| 700 | 1 | |a Tokiwa, Toshiyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Nonaka, Kenichi |e verfasserin |4 aut | |
| 700 | 1 | |a Nakashima, Takuji |e verfasserin |4 aut | |
| 700 | 1 | |a Noguchi, Yoshihiko |e verfasserin |4 aut | |
| 700 | 1 | |a Hirose, Tomoyasu |e verfasserin |4 aut | |
| 700 | 1 | |a Sunazuka, Toshiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Hokari, Rei |e verfasserin |4 aut | |
| 700 | 1 | |a Ishiyama, Aki |e verfasserin |4 aut | |
| 700 | 1 | |a Iwatsuki, Masato |e verfasserin |4 aut | |
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