Elevated phase amplitude coupling as a depression biomarker in epilepsy
Copyright © 2024 Elsevier Inc. All rights reserved..
Depression is prevalent in epilepsy patients and their intracranial brain activity recordings can be used to determine the types of brain activity that are associated with comorbid depression. We performed case-control comparison of spectral power and phase amplitude coupling (PAC) in 34 invasively monitored drug resistant epilepsy patients' brain recordings. The values of spectral power and PAC for one-minute segments out of every hour in a patient's study were correlated with pre-operative assessment of depressive symptoms by Beck Depression Inventory-II (BDI). We identified an elevated PAC signal (theta-alpha-beta phase (5-25 Hz)/gamma frequency (80-100 Hz) band) that is present in high BDI scores but not low BDI scores adult epilepsy patients in brain regions implicated in primary depression, including anterior cingulate cortex, amygdala and orbitofrontal cortex. Our results showed the application of PAC as a network-specific, electrophysiologic biomarker candidate for comorbid depression and its potential as treatment target for neuromodulation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:152 |
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| Enthalten in: |
Epilepsy & behavior : E&B - 152(2024) vom: 15. März, Seite 109659 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Young, James J [VerfasserIn] |
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| Links: |
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| Themen: |
Comorbid Depression |
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| Anmerkungen: |
Date Completed 05.03.2024 Date Revised 10.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.yebeh.2024.109659 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a Depression is prevalent in epilepsy patients and their intracranial brain activity recordings can be used to determine the types of brain activity that are associated with comorbid depression. We performed case-control comparison of spectral power and phase amplitude coupling (PAC) in 34 invasively monitored drug resistant epilepsy patients' brain recordings. The values of spectral power and PAC for one-minute segments out of every hour in a patient's study were correlated with pre-operative assessment of depressive symptoms by Beck Depression Inventory-II (BDI). We identified an elevated PAC signal (theta-alpha-beta phase (5-25 Hz)/gamma frequency (80-100 Hz) band) that is present in high BDI scores but not low BDI scores adult epilepsy patients in brain regions implicated in primary depression, including anterior cingulate cortex, amygdala and orbitofrontal cortex. Our results showed the application of PAC as a network-specific, electrophysiologic biomarker candidate for comorbid depression and its potential as treatment target for neuromodulation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Comorbid Depression | |
| 650 | 4 | |a Depression | |
| 650 | 4 | |a Epilepsy | |
| 650 | 4 | |a Intracranial EEG | |
| 650 | 4 | |a Phase Amplitude Coupling | |
| 650 | 4 | |a Spectral Power | |
| 700 | 1 | |a Chan, Andy Ho Wing |e verfasserin |4 aut | |
| 700 | 1 | |a Jette, Nathalie |e verfasserin |4 aut | |
| 700 | 1 | |a Bender, Heidi A |e verfasserin |4 aut | |
| 700 | 1 | |a Saad, Adam E |e verfasserin |4 aut | |
| 700 | 1 | |a Saez, Ignacio |e verfasserin |4 aut | |
| 700 | 1 | |a Panov, Fedor |e verfasserin |4 aut | |
| 700 | 1 | |a Ghatan, Saadi |e verfasserin |4 aut | |
| 700 | 1 | |a Yoo, Ji Yeoun |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Anuradha |e verfasserin |4 aut | |
| 700 | 1 | |a Fields, Madeline C |e verfasserin |4 aut | |
| 700 | 1 | |a Marcuse, Lara V |e verfasserin |4 aut | |
| 700 | 1 | |a Mayberg, Helen S |e verfasserin |4 aut | |
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