Vitamin B12 Protects Against Genotoxicity Induced by Cisplatin
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Cisplatin is an effective synthetic chemotherapeutic drug used for cancer treatment. Vitamin B12 has been shown to possess anti-genotoxic activity. This study aimed to investigate the effect of vitamin B12 on chromosomal damage induced by cisplatin.
METHODS: The level of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) were measured in cultured human blood lymphocytes treated with cisplatin and/or vitamin B12.
RESULTS: The results showed a significantly elevated frequency of CAs and SCEs of cisplatin-treated cultures compared to the control (P < 0.05). The CAs and SCEs induced by cisplatin were significantly lowered by pretreatment of cell cultures with vitamin B12. In addition, cisplatin caused a slight reduction in the mitotic index (MI), while vitamin B12 did not modulate the effect of cisplatin on MI.
CONCLUSION: Vitamin B12 can protect human lymphocytes against genotoxicity associated with cisplatin.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Current cancer drug targets - (2024) vom: 30. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Al-Bataineh, Wejdan M [VerfasserIn] |
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| Links: |
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| Themen: |
Chromosomal aberrations |
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| Anmerkungen: |
Date Revised 06.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/0115680096284684240110044954 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Cisplatin is an effective synthetic chemotherapeutic drug used for cancer treatment. Vitamin B12 has been shown to possess anti-genotoxic activity. This study aimed to investigate the effect of vitamin B12 on chromosomal damage induced by cisplatin | ||
| 520 | |a METHODS: The level of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) were measured in cultured human blood lymphocytes treated with cisplatin and/or vitamin B12 | ||
| 520 | |a RESULTS: The results showed a significantly elevated frequency of CAs and SCEs of cisplatin-treated cultures compared to the control (P < 0.05). The CAs and SCEs induced by cisplatin were significantly lowered by pretreatment of cell cultures with vitamin B12. In addition, cisplatin caused a slight reduction in the mitotic index (MI), while vitamin B12 did not modulate the effect of cisplatin on MI | ||
| 520 | |a CONCLUSION: Vitamin B12 can protect human lymphocytes against genotoxicity associated with cisplatin | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Vitamin B12 | |
| 650 | 4 | |a chromosomal aberrations | |
| 650 | 4 | |a cisplatin | |
| 650 | 4 | |a mitotic index. | |
| 650 | 4 | |a sister chromatid exchanges | |
| 700 | 1 | |a Alzoubi, Karem H |e verfasserin |4 aut | |
| 700 | 1 | |a Khabour, Omar F |e verfasserin |4 aut | |
| 700 | 1 | |a Mahasneh, Amjad |e verfasserin |4 aut | |
| 700 | 1 | |a Almomani, Enaam M |e verfasserin |4 aut | |
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