The Possible Protective Effect of Taurine on Bisphenol : Induced Structural Changes on the Cerebral Cortex of Rats: Histological and Immunohistochemical Study
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
INTRODUCTION: Bisphenol A (BPA) is a chemical compound that has been used in many industries, such as paints and dental sealants. Taurine is a semi-essential amino acid with antioxidant, anti-inflammatory, and anti-apoptotic actions.
AIM: This study aimed to evaluate the possible protective effect of taurine on BPA-induced structural changes in the cerebral cortex of rats using histological and immunohistochemical methods.
MATERIALS AND METHODS: 35 Wistar rats (180-200 gm) were divided into control: 10 rats; Group I: 5 rats received corn oil (0.5 mL/day); Group II (Bisphenol low dose; BPAL): 5 rats received a low dose of BPA (25 mg/kg/three times/week); Group III (Bisphenol high dose; BPAH): 5 rats received a high dose of BPA (100 mg/kg/ three times/week; Group IV: (BPAL + taurine): 5 rats received taurine 100 mg/kg/day and BPAL (25 mg/kg/three times/week); Group V: (BPAH + taurine): 5 rats received taurine 100mg/kg/day and BPH (100 mg/kg/ three times/week).
RESULTS: BPAL& BPAH groups showed significant dose-dependent histological changes of the neuropil, pyramidal, and neuroglial cells at H&E stained sections, significantly increased GFAP, caspase-3 immunohistochemical reaction with cells positive for Ki67 with many mitotic figures. BPAL + taurine and BPAH + taurine groups showed amelioration of the previously mentioned results.
CONCLUSION: Taurine ameliorated the structural changes induced by BPA in the cerebral cortex of rats.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
CNS & neurological disorders drug targets - (2024) vom: 30. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kandeel, Samah [VerfasserIn] |
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| Links: |
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| Themen: |
Bisphenol A |
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| Anmerkungen: |
Date Revised 01.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/0118715273280701231227100805 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM367885689 |
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| 100 | 1 | |a Kandeel, Samah |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Possible Protective Effect of Taurine on Bisphenol |b Induced Structural Changes on the Cerebral Cortex of Rats: Histological and Immunohistochemical Study |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Revised 01.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a INTRODUCTION: Bisphenol A (BPA) is a chemical compound that has been used in many industries, such as paints and dental sealants. Taurine is a semi-essential amino acid with antioxidant, anti-inflammatory, and anti-apoptotic actions | ||
| 520 | |a AIM: This study aimed to evaluate the possible protective effect of taurine on BPA-induced structural changes in the cerebral cortex of rats using histological and immunohistochemical methods | ||
| 520 | |a MATERIALS AND METHODS: 35 Wistar rats (180-200 gm) were divided into control: 10 rats; Group I: 5 rats received corn oil (0.5 mL/day); Group II (Bisphenol low dose; BPAL): 5 rats received a low dose of BPA (25 mg/kg/three times/week); Group III (Bisphenol high dose; BPAH): 5 rats received a high dose of BPA (100 mg/kg/ three times/week; Group IV: (BPAL + taurine): 5 rats received taurine 100 mg/kg/day and BPAL (25 mg/kg/three times/week); Group V: (BPAH + taurine): 5 rats received taurine 100mg/kg/day and BPH (100 mg/kg/ three times/week) | ||
| 520 | |a RESULTS: BPAL& BPAH groups showed significant dose-dependent histological changes of the neuropil, pyramidal, and neuroglial cells at H&E stained sections, significantly increased GFAP, caspase-3 immunohistochemical reaction with cells positive for Ki67 with many mitotic figures. BPAL + taurine and BPAH + taurine groups showed amelioration of the previously mentioned results | ||
| 520 | |a CONCLUSION: Taurine ameliorated the structural changes induced by BPA in the cerebral cortex of rats | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bisphenol A | |
| 650 | 4 | |a Caspase-3 | |
| 650 | 4 | |a Cerebral Cortex | |
| 650 | 4 | |a Histopathology | |
| 650 | 4 | |a Immunohistochemistry | |
| 650 | 4 | |a Taurine | |
| 700 | 1 | |a Abd-Elsalam, Marwa M |e verfasserin |4 aut | |
| 700 | 1 | |a Abd-Elsalam, Sherief |e verfasserin |4 aut | |
| 700 | 1 | |a Elkaliny, Heba Hassan |e verfasserin |4 aut | |
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