Two-step evolution of HIV-1 budding system leading to pandemic in the human population
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved..
The pandemic HIV-1, HIV-1 group M, emerged from a single spillover event of its ancestral lentivirus from a chimpanzee. During human-to-human spread worldwide, HIV-1 diversified into multiple subtypes. Here, our interdisciplinary investigation mainly sheds light on the evolutionary scenario of the viral budding system of HIV-1 subtype C (HIV-1C), a most successfully spread subtype. Of the two amino acid motifs for HIV-1 budding, the P(T/S)AP and YPxL motifs, HIV-1C loses the YPxL motif. Our data imply that HIV-1C might lose this motif to evade immune pressure. Additionally, the P(T/S)AP motif is duplicated dependently of the level of HIV-1 spread in the human population, and >20% of HIV-1C harbored the duplicated P(T/S)AP motif. We further show that the duplication of the P(T/S)AP motif is caused by the expansion of the CTG triplet repeat. Altogether, our results suggest that HIV-1 has experienced a two-step evolution of the viral budding process during human-to-human spread worldwide.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Cell reports - 43(2024), 2 vom: 27. Feb., Seite 113697 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Konno, Yoriyuki [VerfasserIn] |
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| Links: |
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| Themen: |
Budding |
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| Anmerkungen: |
Date Completed 04.03.2024 Date Revised 04.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.celrep.2024.113697 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM367852179 |
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| 520 | |a Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a The pandemic HIV-1, HIV-1 group M, emerged from a single spillover event of its ancestral lentivirus from a chimpanzee. During human-to-human spread worldwide, HIV-1 diversified into multiple subtypes. Here, our interdisciplinary investigation mainly sheds light on the evolutionary scenario of the viral budding system of HIV-1 subtype C (HIV-1C), a most successfully spread subtype. Of the two amino acid motifs for HIV-1 budding, the P(T/S)AP and YPxL motifs, HIV-1C loses the YPxL motif. Our data imply that HIV-1C might lose this motif to evade immune pressure. Additionally, the P(T/S)AP motif is duplicated dependently of the level of HIV-1 spread in the human population, and >20% of HIV-1C harbored the duplicated P(T/S)AP motif. We further show that the duplication of the P(T/S)AP motif is caused by the expansion of the CTG triplet repeat. Altogether, our results suggest that HIV-1 has experienced a two-step evolution of the viral budding process during human-to-human spread worldwide | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CP: Microbiology | |
| 650 | 4 | |a HIV-1 | |
| 650 | 4 | |a budding | |
| 650 | 4 | |a evolution | |
| 650 | 4 | |a systems virology | |
| 700 | 1 | |a Uriu, Keiya |e verfasserin |4 aut | |
| 700 | 1 | |a Chikata, Takayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Takada, Toru |e verfasserin |4 aut | |
| 700 | 1 | |a Kurita, Jun-Ichi |e verfasserin |4 aut | |
| 700 | 1 | |a Ueda, Mahoko Takahashi |e verfasserin |4 aut | |
| 700 | 1 | |a Islam, Saiful |e verfasserin |4 aut | |
| 700 | 1 | |a Yang Tan, Benjy Jek |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Jumpei |e verfasserin |4 aut | |
| 700 | 1 | |a Aso, Hirofumi |e verfasserin |4 aut | |
| 700 | 1 | |a Kumata, Ryuichi |e verfasserin |4 aut | |
| 700 | 1 | |a Williamson, Carolyn |e verfasserin |4 aut | |
| 700 | 1 | |a Iwami, Shingo |e verfasserin |4 aut | |
| 700 | 1 | |a Takiguchi, Masafumi |e verfasserin |4 aut | |
| 700 | 1 | |a Nishimura, Yoshifumi |e verfasserin |4 aut | |
| 700 | 1 | |a Morita, Eiji |e verfasserin |4 aut | |
| 700 | 1 | |a Satou, Yorifumi |e verfasserin |4 aut | |
| 700 | 1 | |a Nakagawa, So |e verfasserin |4 aut | |
| 700 | 1 | |a Koyanagi, Yoshio |e verfasserin |4 aut | |
| 700 | 1 | |a Sato, Kei |e verfasserin |4 aut | |
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