Autoantibody diagnostics in idiopathic inflammatory myopathy
© 2024. The Author(s)..
Idiopathic inflammatory myopathy (IIM) is a group of rare and heterogeneous systemic diseases that manifest not only in the muscles but also in the skin, joints, and lungs. Initial symptoms can be isolated and variable and thus the diagnosis poses challenges to various specialist groups. As autoantibodies are sometimes the only specific findings that lead to the diagnosis and appropriate treatment, basic knowledge of them is essential. This article explains the available test systems, names the clinical indications necessary for the initiation of autoantibody diagnostics, provides information on the etymology, antigens, synonyms, and first descriptors, describes indirect immunofluorescence on HEp‑2 cells induced by myositis antibodies, and provides clinical-serological associations. The comparison of the autoantibody findings with the clinical symptoms and laboratory findings enables the identification of false positive or false negative laboratory findings in the sense of a plausibility check.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:83 |
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| Enthalten in: |
Zeitschrift fur Rheumatologie - 83(2024), 3 vom: 27. März, Seite 242-249 |
| Sprache: |
Deutsch |
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| Weiterer Titel: |
Autoantikörperdiagnostik bei idiopathisch inflammatorischen Myopathien |
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| Beteiligte Personen: |
Biesen, Robert [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-synthetase syndromes |
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| Anmerkungen: |
Date Completed 28.03.2024 Date Revised 30.03.2024 published: Print-Electronic ErratumIn: Z Rheumatol. 2024 Feb 21;:. - PMID 38381192 Citation Status MEDLINE |
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| doi: |
10.1007/s00393-024-01476-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 500 | |a ErratumIn: Z Rheumatol. 2024 Feb 21;:. - PMID 38381192 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a Idiopathic inflammatory myopathy (IIM) is a group of rare and heterogeneous systemic diseases that manifest not only in the muscles but also in the skin, joints, and lungs. Initial symptoms can be isolated and variable and thus the diagnosis poses challenges to various specialist groups. As autoantibodies are sometimes the only specific findings that lead to the diagnosis and appropriate treatment, basic knowledge of them is essential. This article explains the available test systems, names the clinical indications necessary for the initiation of autoantibody diagnostics, provides information on the etymology, antigens, synonyms, and first descriptors, describes indirect immunofluorescence on HEp‑2 cells induced by myositis antibodies, and provides clinical-serological associations. The comparison of the autoantibody findings with the clinical symptoms and laboratory findings enables the identification of false positive or false negative laboratory findings in the sense of a plausibility check | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Anti-synthetase syndromes | |
| 650 | 4 | |a Etymology | |
| 650 | 4 | |a Immunofluorescence | |
| 650 | 4 | |a Indications | |
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