Perioperative management of long-acting glucagon-like peptide-1 (GLP-1) receptor agonists : concerns for delayed gastric emptying and pulmonary aspiration
Copyright © 2024 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved..
Prescriptions and use of glucagon-like peptide-1 (GLP-1) receptor agonists are increasing dramatically, as indications are expanding from the treatment of diabetes mellitus to weight loss for people with obesity. As GLP-1 receptor agonists delay gastric emptying, perioperative healthcare practitioners could be concerned about an increased risk for pulmonary aspiration during general anaesthesia. We summarise relevant medical literature and provide evidence-based recommendations for perioperative care for people taking GLP-1 receptor agonists. GLP-1 receptor agonists delay gastric emptying; however, ongoing treatment attenuates this effect. The risk of aspiration during general anaesthesia is unknown. However, we advise caution in patients who recently commenced on GLP-1 receptor agonists. After over 12 weeks of treatment, standard fasting times likely suffice to manage the risk of pulmonary aspiration for most otherwise low-risk patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:132 |
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| Enthalten in: |
British journal of anaesthesia - 132(2024), 4 vom: 31. März, Seite 644-648 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
van Zuylen, Mark L [VerfasserIn] |
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| Links: |
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| Themen: |
89750-14-1 |
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| Anmerkungen: |
Date Completed 05.03.2024 Date Revised 05.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bja.2024.01.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2024 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a Prescriptions and use of glucagon-like peptide-1 (GLP-1) receptor agonists are increasing dramatically, as indications are expanding from the treatment of diabetes mellitus to weight loss for people with obesity. As GLP-1 receptor agonists delay gastric emptying, perioperative healthcare practitioners could be concerned about an increased risk for pulmonary aspiration during general anaesthesia. We summarise relevant medical literature and provide evidence-based recommendations for perioperative care for people taking GLP-1 receptor agonists. GLP-1 receptor agonists delay gastric emptying; however, ongoing treatment attenuates this effect. The risk of aspiration during general anaesthesia is unknown. However, we advise caution in patients who recently commenced on GLP-1 receptor agonists. After over 12 weeks of treatment, standard fasting times likely suffice to manage the risk of pulmonary aspiration for most otherwise low-risk patients | ||
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| 650 | 4 | |a gastric emptying | |
| 650 | 4 | |a glucagon-like peptide-1 receptor agonists | |
| 650 | 4 | |a obesity | |
| 650 | 4 | |a pulmonary aspiration | |
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| 650 | 7 | |a Glucagon-Like Peptide 1 |2 NLM | |
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| 700 | 1 | |a Siegelaar, Sarah E |e verfasserin |4 aut | |
| 700 | 1 | |a Plummer, Mark P |e verfasserin |4 aut | |
| 700 | 1 | |a Deane, Adam M |e verfasserin |4 aut | |
| 700 | 1 | |a Hermanides, Jeroen |e verfasserin |4 aut | |
| 700 | 1 | |a Hulst, Abraham H |e verfasserin |4 aut | |
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