Reaching New Heights : A Comprehensive Study of Hand Transplantations in Korea after Institutionalization of Hand Transplantation Law
© Copyright: Yonsei University College of Medicine 2024..
PURPOSE: With the revision of the Organ and Transplantation Act in 2018, the hand has become legal as an area of transplantable organs in Korea. In January 2021, the first hand allotransplantation since legalization was successfully performed, and we have performed a total of three successful hand transplantation since then. By comparing and incorporating our experiences, this study aimed to provide a comprehensive reconstructive solution for hand amputation in Korea.
MATERIALS AND METHODS: Recipients were selected through a structured preoperative evaluation, and hand transplantations were performed at the distal forearm level. Postoperatively, patients were treated with three-drug immunosuppressive regimen, and functional outcomes were monitored.
RESULTS: The hand transplantations were performed without intraoperative complications. All patients had partial skin necrosis and underwent additional surgical procedures in 2 months after transplantation. After additional operations, no further severe complications were observed. Also, patients developed acute rejection within 3 months of surgery, but all resolved within 2 weeks after steroid pulse therapy. Motor and sensory function improved dramatically, and patients were very satisfied with the appearance and function of their transplanted hands.
CONCLUSION: Hand transplantation is a viable reconstructive option, and patients have shown positive functional and psychological outcomes. Although this study has limitations, such as the small number of patients and short follow-up period, we should focus on continued recovery of hand function, and be careful not to develop side effects from immunosuppressive drugs. Through the present study, we will continue to strive for a bright future regarding hand transplantation in Korea.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:65 |
|---|---|
| Enthalten in: |
Yonsei medical journal - 65(2024), 2 vom: 01. Feb., Seite 108-119 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kim, Yo Han [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Hand transplantation |
|---|
| Anmerkungen: |
Date Completed 31.01.2024 Date Revised 02.02.2024 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.3349/ymj.2023.0365 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM36779005X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM36779005X | ||
| 003 | DE-627 | ||
| 005 | 20240202232207.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240130s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3349/ymj.2023.0365 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1278.xml |
| 035 | |a (DE-627)NLM36779005X | ||
| 035 | |a (NLM)38288651 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kim, Yo Han |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Reaching New Heights |b A Comprehensive Study of Hand Transplantations in Korea after Institutionalization of Hand Transplantation Law |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 31.01.2024 | ||
| 500 | |a Date Revised 02.02.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Copyright: Yonsei University College of Medicine 2024. | ||
| 520 | |a PURPOSE: With the revision of the Organ and Transplantation Act in 2018, the hand has become legal as an area of transplantable organs in Korea. In January 2021, the first hand allotransplantation since legalization was successfully performed, and we have performed a total of three successful hand transplantation since then. By comparing and incorporating our experiences, this study aimed to provide a comprehensive reconstructive solution for hand amputation in Korea | ||
| 520 | |a MATERIALS AND METHODS: Recipients were selected through a structured preoperative evaluation, and hand transplantations were performed at the distal forearm level. Postoperatively, patients were treated with three-drug immunosuppressive regimen, and functional outcomes were monitored | ||
| 520 | |a RESULTS: The hand transplantations were performed without intraoperative complications. All patients had partial skin necrosis and underwent additional surgical procedures in 2 months after transplantation. After additional operations, no further severe complications were observed. Also, patients developed acute rejection within 3 months of surgery, but all resolved within 2 weeks after steroid pulse therapy. Motor and sensory function improved dramatically, and patients were very satisfied with the appearance and function of their transplanted hands | ||
| 520 | |a CONCLUSION: Hand transplantation is a viable reconstructive option, and patients have shown positive functional and psychological outcomes. Although this study has limitations, such as the small number of patients and short follow-up period, we should focus on continued recovery of hand function, and be careful not to develop side effects from immunosuppressive drugs. Through the present study, we will continue to strive for a bright future regarding hand transplantation in Korea | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hand transplantation | |
| 650 | 4 | |a Republic of Korea | |
| 650 | 4 | |a transplantation law | |
| 650 | 4 | |a vascularized composite allotransplantation | |
| 650 | 7 | |a Immunosuppressive Agents |2 NLM | |
| 700 | 1 | |a Choi, Yun Rak |e verfasserin |4 aut | |
| 700 | 1 | |a Joo, Dong Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Baek, Woo Yeol |e verfasserin |4 aut | |
| 700 | 1 | |a Suh, Young Chul |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Won Taek |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Jae Yong |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Sang Chul |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Sang Kyum |e verfasserin |4 aut | |
| 700 | 1 | |a Ryu, Hyang Joo |e verfasserin |4 aut | |
| 700 | 1 | |a Jeon, Kyung Ock |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Won Jai |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Jong Won |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Yonsei medical journal |d 1963 |g 65(2024), 2 vom: 01. Feb., Seite 108-119 |w (DE-627)NLM00031269X |x 1976-2437 |7 nnns |
| 773 | 1 | 8 | |g volume:65 |g year:2024 |g number:2 |g day:01 |g month:02 |g pages:108-119 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3349/ymj.2023.0365 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 65 |j 2024 |e 2 |b 01 |c 02 |h 108-119 | ||